{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:10:10Z","timestamp":1745467810791,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>The mechanism by which dietary K&lt;sup&gt;+&lt;\/sup&gt; restriction induces distal\u2013nephron Li&lt;sup&gt;+&lt;\/sup&gt; reabsorption was investigated by administration of bendroflumethiazide (BFTZ) or vehicle in conscious Wistar rats. Changes in fractional excretion of Li&lt;sup&gt;+&lt;\/sup&gt; following administration of amiloride (\u0394FE&lt;sub&gt;Li&lt;\/sub&gt;) were used as an index of distal tubular Li&lt;sup&gt;+&lt;\/sup&gt; reabsorption. The results revealed an absence of distal tubular Li&lt;sup&gt;+&lt;\/sup&gt; reabsorption in K&lt;sup&gt;+&lt;\/sup&gt;\u2013replete rats (\u0394FE&lt;sub&gt;Li&lt;\/sub&gt; = 3.6\u00b12.4%), in contrast to K&lt;sup&gt;+&lt;\/sup&gt; restriction in which \u0394FE&lt;sub&gt;Li&lt;\/sub&gt; was 24.0\u00b12.7%. The distal tubular Li&lt;sup&gt;+&lt;\/sup&gt; reabsorption in K&lt;sup&gt;+&lt;\/sup&gt;\u2013depleted rats was significantly reduced by preadministration of BFTZ (\u0394FE&lt;sub&gt;Li&lt;\/sub&gt; = 9.2\u00b10.9%). The fractions of Li&lt;sup&gt;+&lt;\/sup&gt; and Na&lt;sup&gt;+&lt;\/sup&gt; reabsorbed in the amiloride\u2013sensitive segment were different in K&lt;sup&gt;+&lt;\/sup&gt;\u2013replete rats (9\u00b16 vs. 60\u00b16%), but similar in K&lt;sup&gt;+&lt;\/sup&gt;\u2013depleted rats (61\u00b15 vs. 73\u00b14%). BFTZ administration to K&lt;sup&gt;+&lt;\/sup&gt;\u2013depleted rats resulted in a proportional decrease in these fractions, suggesting competition between Na&lt;sup&gt;+&lt;\/sup&gt; and Li&lt;sup&gt;+&lt;\/sup&gt; for reabsorption in the distal\u2013nephron segment during K&lt;sup&gt;+&lt;\/sup&gt; depletion. These results are compatible with the hypothesis that during K&lt;sup&gt;+&lt;\/sup&gt; depletion the reabsorption of Li&lt;sup&gt;+ &lt;\/sup&gt;in the distal\u2013nephron segment is competitively inhibited by Na&lt;sup&gt;+&lt;\/sup&gt;.<\/jats:p>","DOI":"10.1159\/000025958","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"83-88","source":"Crossref","is-referenced-by-count":1,"title":["Mechanisms of Distal\u2013Nephron Li&lt;sup&gt;+&lt;\/sup&gt;  Reabsorption during Dietary K&lt;sup&gt;+&lt;\/sup&gt;  Restriction in Rats"],"prefix":"10.1159","volume":"23","author":[{"given":"Mahmoud","family":"Emamifar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Shalmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90406-8"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/25958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/25958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:52:50Z","timestamp":1745466770000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000025958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":1,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000025958","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2000]]}}}