{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:36:04Z","timestamp":1771846564592,"version":"3.50.1"},"reference-count":2,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1998,12,2]],"date-time":"1998-12-02T00:00:00Z","timestamp":912556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,12,2]],"date-time":"1998-12-02T00:00:00Z","timestamp":912556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>As a part of the WHO Age-Associated Dementia Project, Chile has been participating in a cross-national survey on dementia frequency and determinants since 1989. In the present study, apolipoprotein E (ApoE) polymorphism genotypes have been compared in 95 patients with Alzheimer\u2019s disease (AD) (mean age 80.7; 95% CI 79.2\u201382.2, range 66\u201397) and 187 healthy people (mean age 78.2; 95% CI 77.2\u201379.2, range 65\u201393). Isoelectric focusing and immunoblotting with anti-human ApoE polyclonal antibody were used to determine the distribution of ApoE genotypes. Dementia was diagnosed according to DSM-III-R and ICD-10 clinical criteria. The diagnosis of probable or possible AD was made according to the NINCDS-ADRDA criteria. The ApoE allele frequencies in healthy people were calculated to be \u03c32 = 0.07, \u03c33 = 0.74 and \u03c34 = 0.19. In the probable AD disease group, the frequencies were \u03c32 = 0.08, \u03c33 = 0.52 and \u03c34 = 0.40. The odds ratio (OR) for \u03c34 carriers compared with non-\u03c34 carriers was estimated to be 2.9 (95% CI 1.7\u20135.1). Taking the genotype \u03c33\/\u03c33 as the reference group, the OR for the \u03c34\/\u03c34 genotype was estimated to be 12.8 (95% CI 3.9\u201347.6) and for \u03c33\/\u03c34 subjects it was 2.4 (1.3\u20134.5). These results support the association between ApoE \u03c34 allele with late-onset AD in a Chilean population.<\/jats:p>","DOI":"10.1159\/000026195","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"48-52","source":"Crossref","is-referenced-by-count":23,"title":["Apolipoprotein E Polymorphism in Elderly Chilean People with Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"18","author":[{"given":"Pilar","family":"Quiroga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Albala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Urquidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heberto","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341202"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/26195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/26195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:54:44Z","timestamp":1745466884000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000026195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12,2]]},"references-count":2,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000026195","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12,2]]}}}