{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:11:35Z","timestamp":1745554295059,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Suicidal behavior in depressed patients is associated with low central serotonin. Thus, platelet serotonin uptake in relation to suicidal behavior in depression was examined. &lt;i&gt;Methods:&lt;\/i&gt; Depressed patients who had never attempted suicide (n = 23) were compared with depressed patients who had never attempted suicide (n = 26) and normal controls (n = 71) for platelet serotonin uptake. &lt;i&gt;Results:&lt;\/i&gt; Depressed patients who had a lifetime history of a suicide attempt had a significantly greater apparent Michaelis constant (K&lt;sub&gt;m&lt;\/sub&gt;) of platelet serotonin uptake than either depressed patients who had never attempted suicide or controls. Patients rated high for current suicidal ideation at the index admission had significantly higher K&lt;sub&gt;m&lt;\/sub&gt; values than patients rated low. Also, patients who reattempted or committed suicide during a 5-year follow-up period had significantly higher K&lt;sub&gt;m&lt;\/sub&gt; values than controls. Among women patients who had attempted suicide there was a significant correlation between extrapunitive hostility scores and K&lt;sub&gt;m&lt;\/sub&gt; values. &lt;i&gt;Conclusion:&lt;\/i&gt; The serotonin transporter warrants further study in relation to suicidal behavior in depression.<\/jats:p>","DOI":"10.1159\/000026563","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"71-75","source":"Crossref","is-referenced-by-count":20,"title":["Suicidal Behavior in Depression: Relationship to Platelet Serotonin Transporter"],"prefix":"10.1159","volume":"39","author":[{"given":"Alec","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90576-N"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90106-A"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(88)90121-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90192-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00212-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90488-X"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/26563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/26563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:59:17Z","timestamp":1745467157000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000026563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000026563","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[1999]]}}}