{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:27:28Z","timestamp":1790886448692,"version":"4.1.0"},"reference-count":6,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>We have previously shown that low density lipoprotein receptor-deficient (LDL-RD) mice immunized with \u03b2&lt;sub&gt;2&lt;\/sub&gt;-glycoprotein I (\u03b22GPI; a target of autoimmune anticardiolipin antibodies) developed enhanced early atherosclerosis, when fed a normal chow diet. The current study was undertaken to evaluate the effect of immunization with \u03b22GPI and the addition of a high fat diet on the progression of atherosclerosis in the apolipoprotein E (ApoE)-deficient mouse. Six-week-old female ApoE-deficient mice (n = 10) were immunized subcutaneously with either human \u03b22GPI or with ovalbumin, both emulsified in complete Freund\u2019s adjuvant and fed a high fat diet for 6 weeks. The \u03b22GPI-immunized mice were found to develop accelerated atherosclerosis when compared with their ovalbumin-immunized littermates (aortic lesion area of 137,500 \u00b1 13,801 vs. 72,444 \u00b1 14,465\u00a0\u00b5m&lt;sup&gt;2&lt;\/sup&gt;, respectively; p = 0.0067). The \u03b22GPI-immunized mice developed high titers of anti-\u03b22GPI antibodies, 10 days after the procedure, which were sustained until the sacrifice. LDL extracted from both study groups displayed similar susceptibility to ex vivo oxidation. These results confirm our previous study in which we found increased atherosclerosis in \u03b22GPI-immunized LDL-RD mice fed a chow diet. In the current study we show that the proatherogenic effect of \u03b22GPI immunization is maintained despite high cholesterol levels and is not associated with increased susceptibility of LDL to ex vivo oxidation.<\/jats:p>","DOI":"10.1159\/000028046","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"19-25","source":"Crossref","is-referenced-by-count":61,"title":["Enhancement of Atherosclerosis in Beta-2-Glycoprotein I-Immunized Apolipoprotein E-Deficient Mice"],"prefix":"10.1159","volume":"67","author":[{"given":"Arnon","family":"Afek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Gilburd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Shaish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pnina","family":"Keren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zora","family":"Janackovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juri","family":"Kopolovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Harats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1999,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91477-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1994.1032"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90362-G"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90926-T"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/353265a0"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/28046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/28046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:12:57Z","timestamp":1745467977000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000028046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000028046","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"value":"1015-2008","type":"print"},{"value":"1423-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}