{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T22:25:46Z","timestamp":1769207146331,"version":"3.49.0"},"reference-count":3,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; Spina bifida is an important birth defect. Its incidence differs from one country to another due to different factors. The aims of this study were: (1)\u00a0to estimate the incidence of spina bifida in Al-Madinah Al-Munawarah and compare it with the Eastern part of the Kingdom, and (2)\u00a0to find out if consanguinity is a risk factor. &lt;i&gt;Methodology:&lt;\/i&gt; A prospective study was conducted over the period from April 1996 to March 1997 in the city of Al-Madinah Al-Munawarah, Western Province, Saudi Arabia. New cases of spina bifida were studied and compared to a control group of 72 cases. &lt;i&gt;Results:&lt;\/i&gt; During the study period, 18 cases of spina bifida were detected. The incidence was 1.09 per 1,000 live births. The male to female ratio was 2:1; however, this was not statistically significant. Consanguinity of the parents was found in 89% of the spina bifida parents and only 67% of the controls (p &lt; 0.0005). &lt;i&gt;Conclusion:&lt;\/i&gt; (1)\u00a0The incidence of spina bifida in the city of Al-Madinah Al-Munawarah was similar to that reported from the Eastern Province of Saudi Arabia. (2)\u00a0The consanguinity of the parents was a significant risk factor.<\/jats:p>","DOI":"10.1159\/000028890","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"10-12","source":"Crossref","is-referenced-by-count":20,"title":["Spina bifida in Saudi Arabia: Is Consanguinity among the Parents a Risk Factor?"],"prefix":"10.1159","volume":"32","author":[{"given":"Waleed R.","family":"Murshid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960102)61:1<30::AID-AJMG6>3.0.CO;2-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970211)68:4<472::AID-AJMG20>3.0.CO;2-O"}],"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/28890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/28890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:18:55Z","timestamp":1745468335000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000028890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":3,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000028890","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"value":"1016-2291","type":"print"},{"value":"1423-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000]]}}}