{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:40:03Z","timestamp":1745469603638,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Weight loss and skeletal muscle wasting are common in patients with chronic obstructive pulmonary disease (COPD) and can influence the course and the prognosis of COPD. Hypophosphatemia is a pathologic status often characterized by muscle weakness and is a frequent laboratory finding in these patients. &lt;i&gt;Objective:&lt;\/i&gt; The aim of the present study was to evaluate the effect of an organic phosphate (fructose 1,6-diphosphate, FDP) administration on respiratory performance in 45 malnourished COPD patients in stable clinical conditions. &lt;i&gt;Methods:&lt;\/i&gt; Physiologic evaluation including spirometry, maximal voluntary ventilation (MMV), elevated arm test, maximal mouth pressures (PImax and PEmax), respiratory response to CO&lt;sub&gt;2&lt;\/sub&gt;, oxygen (PaO&lt;sub&gt;2&lt;\/sub&gt;) and carbon dioxide (PaCO&lt;sub&gt;2&lt;\/sub&gt;) arterial tension, a visual analogic scale (VAS) to measure dyspnea, and complete blood tests were done at the beginning and again at the end of the study. &lt;i&gt;Results:&lt;\/i&gt; After FDP administration, there was a significant increase in PImax (43.0 \u00b1 18.3\u00a0cm H&lt;sub&gt;2&lt;\/sub&gt;O before treatment vs. 49.8 \u00b1 14.9\u00a0cm H&lt;sub&gt;2&lt;\/sub&gt;O after treatment; p &lt; 0.005). This did not occur in the placebo group (40.3 \u00b1 17.4\u00a0cm H&lt;sub&gt;2&lt;\/sub&gt;O before treatment vs. 42.6 \u00b1 20.1\u00a0cm H&lt;sub&gt;2&lt;\/sub&gt;O after treatment, nonsignificant). There was also a trend of VAS to decrease and of MVV to increase. &lt;i&gt;Conclusions:&lt;\/i&gt; These results show that FDP administration may be useful in the management of malnourished COPD patients, especially in increasing their respiratory muscle strength.<\/jats:p>","DOI":"10.1159\/000029483","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"177-182","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Intravenous Fructose 1,6-Diphosphate Administration in Malnourished Chronic Obstructive Pulmonary Disease Patients with Chronic Respiratory Failure"],"prefix":"10.1159","volume":"67","author":[{"given":"Francesca","family":"Marchesani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Valerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Dardes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Viglianti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio M.","family":"Sanguinetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90522-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90234-9"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/29483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/29483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:14Z","timestamp":1745468714000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000029483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":2,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2000,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000029483","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2000]]}}}