{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:33:07Z","timestamp":1772541187319,"version":"3.50.1"},"reference-count":4,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>The search for effective inhibitors of transdermal drug-induced contact sensitization was directed to dermal mast-cell-degranulating agents (MCDA). Human skin organ cultures were employed to test whether &lt;i&gt;cis&lt;\/i&gt;-urocanic acid (C-UA) and other potential MCDAs cause mast cell degranulation. These were then tested for their ability to inhibit the induction phase of the contact hypersensitivity reaction (CHR). C-UA at 1\u00a0\u03bcg\/ml significantly depleted mast cell chymase, whereas &lt;i&gt;trans&lt;\/i&gt;-urocanic acid (T-UA) was relatively ineffective. C-UA, but not T-UA, induced local effects of liberated mast cell TNF-\u03b1, as detected by E-selectin expression on the microvascular dermal endothelium. C-UA significantly reduced (&gt;70%) the ear swelling response in Balb\/c mice, when applied 24\u00a0h prior to application of a sensitizing amount of dinitrochlorobenzene (DNCB), and induced a prolonged (&gt;3 weeks) state of immune tolerance (&gt;40%). Similar effects on local immunosuppression of CHR were observed with topical chloroquine and capsaicin, while cromolyn, a mast cell membrane stabilizer, was unable to inhibit DNCB-induced CHR. It is suggested that MCDAs may interfere with downstream events associated with accessory cell function.<\/jats:p>","DOI":"10.1159\/000029842","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"18-27","source":"Crossref","is-referenced-by-count":50,"title":["&lt;i&gt;cis&lt;\/i&gt;-Urocanic Acid Induces Mast Cell Degranulation and Release of Preformed TNF--\u03b1: A Possible Mechanism Linking UVB and &lt;i&gt;cis&lt;\/i&gt;-Urocanic Acid to Immunosuppression of Contact Hypersensitivity"],"prefix":"10.1159","volume":"12","author":[{"given":"John J.","family":"Wille","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agis F.","family":"Kydonieus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George F.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.125.4.502"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.1.84"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.123.11.1548"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.10.1725"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/29842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/29842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:27:50Z","timestamp":1745468870000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000029842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":4,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[1999,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000029842","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}