{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:50:08Z","timestamp":1761763808357,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[1998]]},"abstract":"We studied the effects of 8 weeks of streptozotocin (STZ)-induced diabetes on the density and the pharmacological properties of \u03b1<sub>1<\/sub>-adrenoceptors in the rat prostate using receptor-binding experiments with [<sup>125<\/sup>I]iodo-2[\u03b2-(4-hydroxyphenyl)-ethylaminomethyl]tetralone [<sup>125<\/sup>I]HEAT. Saturation experiments showed the presence of specific [<sup>125<\/sup>I]HEAT-binding sites in the control and diabetic rat prostate and that the induction of diabetes significantly decreased the density of [<sup>125<\/sup>I]HEAT-binding sites in the rat prostate. [<sup>125<\/sup>I]HEAT-binding sites in the prostate of both groups were inhibited by prazosin (nonselective), spiperone (\u03b1<sub>1B<\/sub>-selective), WB4101 and 5-methylurapidil (\u03b1<sub>1A<\/sub>-selective) and BMY7378 (\u03b1<sub>1D<\/sub>-selective) with the following rank order of K<sub>i<\/sub> values: prazosin < WB4101 < 5-methylurapidil < spiperone < BMY7378, indicating a similar pharmacological profile of \u03b1<sub>1<\/sub>-adrenoceptor in the 2 groups.Comparing the K<sub>i<\/sub> values of the rat prostate with those obtained from the rat submaxillary gland (\u03b1<sub>1A<\/sub>), rat spleen (\u03b1<sub>1B<\/sub>), rat vas deferens (\u03b1<sub>1A<\/sub> + \u03b1<sub>1B<\/sub>) and those reported for cloned \u03b1<sub>1D<\/sub>, indicates the predominance of the \u03b1<sub>1A<\/sub> + \u03b1<sub>1B<\/sub> or the \u03b1<sub>1A<\/sub> subtype in the rat prostate. The present study demonstrates that STZ-induced diabetes downregulates the expression of \u03b1<sub>1<\/sub>-adrenoceptor in the rat prostate, without significantly affecting the receptor subtype specificity.<\/jats:p>","DOI":"10.1159\/000030311","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"147-153","source":"Crossref","is-referenced-by-count":13,"title":["Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes"],"prefix":"10.1159","volume":"61","author":[{"given":"Kazuhiko","family":"Nishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harris E.","family":"Foster Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamshid","family":"Latifpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90245-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90223-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)00751-R"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90424-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(87)90107-X"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/30311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/30311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:29:12Z","timestamp":1745468952000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000030311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1999,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000030311","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[1998]]}}}