{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:50:22Z","timestamp":1761763822502,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; A prospective monocenter open study was carried out to evaluate if generalized phototoxic skin reactions occur after intravesical application of 5-aminolevulinic acid (ALA) for fluorescence diagnosis of superficial bladder carcinomas. &lt;i&gt;Patients and Methods:&lt;\/i&gt; On 21 patients, skin phototoxicity was determined prior to as well as 4, 8 and 28\u00a0h after intravesical instillation of a 3% ALA solution by exposing small skin areas to a progressively graded series of defined UVA-light doses (n = 9; 5\u201380 J\/cm&lt;sup&gt;2&lt;\/sup&gt;). &lt;i&gt;Results:&lt;\/i&gt; Prior to ALA instillation, erythema or pigmentation as signs of cutaneous phototoxicity occurred at an UVA-light dose of 28 \u00b1 1.5 J\/cm&lt;sup&gt;2&lt;\/sup&gt; (mean \u00b1 SEM). A reduction of the minimal phototoxic dose (MPD) was not detected 4 (28 \u00b1 1.9 J\/cm&lt;sup&gt;2&lt;\/sup&gt;), 8 (28 \u00b1 1.6 J\/cm&lt;sup&gt;2&lt;\/sup&gt;) and 28\u00a0h (28 \u00b1 1.5 J\/cm&lt;sup&gt;2&lt;\/sup&gt;) after ALA instillation. Consequently phototoxic reactions were not observed. &lt;i&gt;Conclusions:&lt;\/i&gt; A reduction of MPD for UVA was not detected. Therefore, it is not necessary to protect the skin of patients from ambient or daylight after intravesical instillation of ALA for fluorescence diagnosis.<\/jats:p>","DOI":"10.1159\/000030511","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"126-128","source":"Crossref","is-referenced-by-count":13,"title":["No Generalized Skin Phototoxicity after Intravesical Application of 5-Aminolevulinic Acid for Fluorescence Diagnosis ofSuperficial Bladder Cancer"],"prefix":"10.1159","volume":"64","author":[{"given":"T.","family":"Filbeck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.B.","family":"Wimmershoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Pichlmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Karrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.F.","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.-M.","family":"Szeimies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"R\u00f6ssler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199601000-00038"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1997)20:4<402::AID-LSM5>3.0.CO;2-U"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/30511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/30511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:33Z","timestamp":1745469093000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000030511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":2,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000030511","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2000]]}}}