{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:33:50Z","timestamp":1789947230594,"version":"4.0.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Acquired reciprocal chromosomal translocations that involve chromosome bands 5q31\u201333 are associated with a significant minority of patients with &lt;i&gt;BCR-ABL-&lt;\/i&gt;negative chronic myeloid leukemias. The most common abnormality is the t(5;12)(q33;p13), which fuses the &lt;i&gt;ETV6\/TEL&lt;\/i&gt; gene to the platelet-derived growth factor receptor-\u03b2 &lt;i&gt;(PDGFRB)&lt;\/i&gt;, a receptor tyrosine kinase that maps to 5q33. &lt;i&gt;PDGFRB&lt;\/i&gt; is disrupted by other translocations and to date four additional partner genes &lt;i&gt;(H4&lt;\/i&gt;, &lt;i&gt;HIP1&lt;\/i&gt;, &lt;i&gt;CEV14&lt;\/i&gt; and &lt;i&gt;Rab5)&lt;\/i&gt; have been reported. Clinically, most patients present with a myeloproliferative disorder (MPD) with eosinophilia, eosinophilic leukemia or chronic myelomonocytic leukemia and thus fall into the broader category of myeloproliferative disorders\/myelodysplastic syndromes (MPD\/MDS). With the advent of targeted signal transduction therapy, patients with rearrangement of &lt;i&gt;PDGFRB &lt;\/i&gt;might be better classified as a distinct subgroup of MPD\/MDS.<\/jats:p>","DOI":"10.1159\/000046641","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"113-122","source":"Crossref","is-referenced-by-count":125,"title":["Myeloproliferative Disorders with Translocations of Chromosome 5q31\u201335: Role of the Platelet-Derived Growth Factor Receptor Beta"],"prefix":"10.1159","volume":"107","author":[{"given":"E. 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