{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:07:58Z","timestamp":1791929278111,"version":"4.3.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2001]]},"abstract":"<i>Background:<\/i> Hemodiafiltration (HDF) is effective in delaying the surgical need for carpal tunnel syndrome in chronic hemodialysis patients, however, predialysis \u03b2<sub>2<\/sub>-microglobulin levels were not reduced in most short-term studies. The aim of this study was to assess the effect of long-term and differing frequencies of on-line HDF on serum \u03b2<sub>2<\/sub>-microglobulin levels in comparison to high-flux hemodialysis (HD). <i>Methods:<\/i> One hundred and twelve patients in the Chang Gung Memorial Hospital Dialysis Unit were divided into three groups to receive different frequencies of on-line HDF alternating with high-flux HD. Group\u00a01 was treated once with HDF and twice with high-flux HD per week (n = 21). Group\u00a02 was treated twice with HDF and once with high-flux HD per week (n = 33). Group\u00a03 was treated with HDF three times per week (n = 58). Analysis was performed to compare the serum \u03b2<sub>2<\/sub>-microglobulin levels in these groups and to high-flux HD. <i>Results:<\/i> After receiving HDF for a mean of 7.9 months, group\u00a03 patients had a reduced predialysis \u03b2<sub>2<\/sub>-microglobulin level (22.2 \u00b15.3 vs. 34.8 \u00b16.3 mg\/l, p < 0.001), postdialysis \u03b2<sub>2<\/sub>-microglobulin level (6.3 \u00b1 2.0 vs. 13.8 \u00b1 6.8 mg\/l, p < 0.001) and an increased \u03b2<sub>2<\/sub>-microglobulin reduction rate (76.1 \u00b1 5.6 vs. 61.1 \u00b1 13.3%, p = 0.03) when compared to high-flux HD. A significant improvement in URR (p = 0.0004), Kt\/V (p = 0.0002) and TAC urea levels (p = 0.006) but not nPCR (p = 0.122) was found after patients had been treated with on-line HDF. The \u03b2<sub>2<\/sub>-microglobulin reduction rate was positively correlated with the overall volume of the replacement solution per session (p < 0.0001). Patients in group\u00a03 had lower predialysis \u03b2<sub>2<\/sub>-microglobulin levels than those in group\u00a01 and group\u00a02 (22.2 \u00b1 5.3 vs. 25.2 \u00b1 7.2 vs. 26.0 \u00b1 4.2 mg\/l, p = 0.02). Furthermore, an inverse correlation was found between the predialysis \u03b2<sub>2<\/sub>-microglobulin level and the duration of HDF, if patients were treated for more than 12 months (p = 0.031). <i>Conclusion:<\/i> On-line HDF has an increased dialysis efficiency compared to high-flux dialysis. Long-term HDF further reduced predialysis \u03b2<sub>2<\/sub>-microglobulin levels, thus, it may provide an improved modality for renal replacement therapy.<\/jats:p>","DOI":"10.1159\/000046958","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"301-307","source":"Crossref","is-referenced-by-count":54,"title":["Long-Term On-Line Hemodiafiltration Reduces Predialysis Beta-2-Microglobulin Levels in Chronic Hemodialysis Patients"],"prefix":"10.1159","volume":"19","author":[{"given":"Chun-Liang","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chen","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Tung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Ching","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000013317"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/46958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/46958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:47:22Z","timestamp":1745466442000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000046958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":1,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000046958","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}