{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:27:14Z","timestamp":1760099234153,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The analysis of heart rate variability (HRV) is a useful tool to evaluate cardiac autonomic modulation, which is frequently impaired in chronic uremia. &lt;i&gt;Aims:&lt;\/i&gt; The aim of this study was to evaluate HRV in chronic uremics and to separately investigate the acute changes induced by volume depletion and solute removal during a hemodialysis session. &lt;i&gt;Methods:&lt;\/i&gt; Fourteen uremic patients (8 males and 6 females, aged 50 \u00b1 15 years) on maintenance hemodialysis and 14 sex- and age-matched healthy controls were studied. Both groups underwent ambulatory electrocardiogram monitoring to evaluate the HRV time and frequency domain indices. The hemodialysis session was performed by 1\u00a0h of high-rate isolated ultrafiltration followed by 3\u00a0h of bicarbonate diffusive procedure. &lt;i&gt;Results:&lt;\/i&gt; In uremic patients, the overall variability in the frequency [low-frequency power (LF): 505 \u00b1 473, vs. 1,446 \u00b1 654; high-frequency power (HF): 133 \u00b1 162 vs. 512 \u00b1 417; p &lt; 0.001] and time domain indices (standard deviation of normal R-R intervals: 101.9 \u00b1 33.3 vs. 181.7 \u00b1 44.1\u00a0ms; p &lt; 0.001) was markedly reduced compared to controls, whereas mean heart rate (83 \u00b1 12.4 vs. 60.9 \u00b1 8.8 bpm; p &lt; 0.001) and LF\/HF ratio (5.8 \u00b1 3.5 vs. 2.2 \u00b1 0.8; p &lt; 0.001) were increased. Isolated ultrafiltration produced a marked further decrease in HRV indices, but the subsequent diffusive hemodialysis procedure, with a low ultrafiltration rate, made HRV increase again. &lt;i&gt;Conclusions:&lt;\/i&gt; Chronic uremics showed abnormal autonomic modulation with sympathetic-vagal imbalance. The unbalanced hypersympathetic response to body fluid depletion is related to the ultrafiltration rate. Low interdialytic weight gain and a low ultrafiltration rate, associated with adequate hemodialysis, should be the preferable strategy for uremic patients with autonomic dysfunction.<\/jats:p>","DOI":"10.1159\/000046970","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"395-400","source":"Crossref","is-referenced-by-count":20,"title":["Changes in Heart Rate Variability in Chronic Uremic Patients during Ultrafiltration and Hemodialysis"],"prefix":"10.1159","volume":"19","author":[{"given":"Fabio","family":"Galetta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adamasco","family":"Cupisti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Franzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Caprioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Rindi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Barsotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00690.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)88103-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000045387"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000057480"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/46970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/46970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:47:33Z","timestamp":1745466453000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000046970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":4,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000046970","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"type":"print","value":"0253-5068"},{"type":"electronic","value":"1421-9735"}],"subject":[],"published":{"date-parts":[[2001]]}}}