{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:32:30Z","timestamp":1772271150049,"version":"3.50.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Previous studies have shown a reduction of dopaminergic D&lt;sub&gt;2&lt;\/sub&gt; receptors (D&lt;sub&gt;2&lt;\/sub&gt;R) in the striatum after hypoxia-ischemia in newborn rats. We show here an early and transient reduction of mRNA D&lt;sub&gt;2&lt;\/sub&gt;R in nonatrophic brains following hypoxia-ischemia. The left carotid artery of P7 rats was ligated followed by hypoxia for 2\u00a0h. The rats were sacrificed after 24\u00a0h, 48\u00a0h and 14 days. D&lt;sub&gt;2&lt;\/sub&gt;R mRNA was studied by in situ hybridization, the cell number by conventional histology, and neuronal and astrocyte differentiation by immunohistochemistry. A 20% reduction of striatal mRNA D&lt;sub&gt;2&lt;\/sub&gt;R occurred 24\u00a0h after hypoxia-ischemia, whereas no reduction was observed after 48\u00a0h and 14 days. There were no differences in total cell number and in the expression of neuronal (MAP-1, MAP-2) and astrocyte (GFAP) markers between both brain hemispheres nor between control and hypoxia-ischemia animals. The early decrease in mRNA D&lt;sub&gt;2&lt;\/sub&gt;R could explain the delayed reduced D&lt;sub&gt;2&lt;\/sub&gt;R after neonatal hypoxia-ischemia.<\/jats:p>","DOI":"10.1159\/000047123","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"68-73","source":"Crossref","is-referenced-by-count":3,"title":["mRNA D&lt;sub&gt;2&lt;\/sub&gt; Dopaminergic Receptor Expression after Hypoxia-Ischemia in Rat Immature Brain"],"prefix":"10.1159","volume":"80","author":[{"given":"Sylvain","family":"Cantagrel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Gressens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Bodard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie-Laure","family":"Suc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Laugier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Guilloteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Chalon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00605-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199609)24:1<79::AID-SYN8>3.0.CO;2-D"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)90184-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(96)00053-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90460-B"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90357-Y"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)90227-5"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:20Z","timestamp":1745466560000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000047123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000047123","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}