{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:11:04Z","timestamp":1745554264625,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>The aim of this study was to identify the mechanisms that regulate dopamine release (DA&lt;sub&gt;r&lt;\/sub&gt;) by the hypoxic carotid body (CB) during development. CBs sampled from adult (n = 58) and 10-day-old (n = 53) rabbits were incubated for 1 h in a medium equilibrated with 8% O&lt;sub&gt;2&lt;\/sub&gt; in N&lt;sub&gt;2&lt;\/sub&gt; without or in the presence of the specific DA D&lt;sub&gt;2&lt;\/sub&gt; receptor antagonist domperidone, 0.01, 0.1 and 1 \u00b5&lt;i&gt;M&lt;\/i&gt;. DA and its major metabolite DOPAC were measured in the CB (DA&lt;sub&gt;CB&lt;\/sub&gt;) and in the medium (DA&lt;sub&gt;r&lt;\/sub&gt;) by HPLC+ED. In adults, each concentration of domperidone significantly decreased DA&lt;sub&gt;CB&lt;\/sub&gt; and increased DA&lt;sub&gt;r&lt;\/sub&gt;, compared with control (p &lt; 0.01). In contrast, in 10-day old, only the 1 \u00b5&lt;i&gt;M&lt;\/i&gt; domperidone concentration decreased DA&lt;sub&gt;CB&lt;\/sub&gt; and increased DA&lt;sub&gt;r&lt;\/sub&gt; compared with control (p &lt; 0.001). The data show that domperidone increases CB DA&lt;sub&gt;r&lt;\/sub&gt; in response to hypoxia in a concentration- and age-dependent manner and suggest this response depends, in part, on the functional maturation of CB DA D&lt;sub&gt;2&lt;\/sub&gt; receptors.<\/jats:p>","DOI":"10.1159\/000047149","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"235-238","source":"Crossref","is-referenced-by-count":8,"title":["Age-Dependent Effect of Domperidone on Dopamine Release by the Hypoxic Carotid Body in the Rabbit"],"prefix":"10.1159","volume":"80","author":[{"given":"Aida","family":"Bairam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Kinkead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Marchal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90058-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1076\/apab.105.1.3.13145"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(85)90043-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90079-C"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:33Z","timestamp":1745466573000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000047149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":4,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000047149","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2001]]}}}