{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:11:06Z","timestamp":1745554266040,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To examine whether plasma or urine elastase \u03b1&lt;sub&gt;1&lt;\/sub&gt;-proteinase inhibitor (E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI) levels could be used as a diagnostic marker of urinary tract infection (UTI) in neonates. &lt;i&gt;Subjects and Methods:&lt;\/i&gt; Plasma and urine E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI levels were measured by immunoassay in 23 neonates with UTI at the time of admission and 72 h after the onset of treatment and in 10 \u2018normal\u2019 neonates (i.e. with trivial problems). Additionally E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI plasma levels were measured in 15 neonates with septicemia. &lt;i&gt;Results:&lt;\/i&gt; E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI plasma levels did not differ between normal neonates and those with UTI. Urine E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI levels were significantly higher in neonates with UTI on admission compared to normal neonates. A significant decrease in urine E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI levels was noticed 72 h after the onset of treatment in all but 2 neonates in whom infection persisted. In this study, we have found that the urine E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI concentration at a cutoff level of 48 \u00b5g\/l had a sensitivity of 83%, a specificity of 90%, a positive predictive value of 95% and a negative predictive value of 69% for the diagnosis of neonatal UTI. &lt;i&gt;Conclusion:&lt;\/i&gt; Elevated levels of E-\u03b1&lt;sub&gt;1&lt;\/sub&gt;-PI in urine seem to be a useful tool for the diagnosis of UTI in neonates (even in those that have already been started on antibiotics) and possibly a valuable marker for early recognition of treatment failure.<\/jats:p>","DOI":"10.1159\/000047194","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"109-112","source":"Crossref","is-referenced-by-count":1,"title":["Plasma and Urine Elastase Alpha-1-Proteinase Inhibitor Levels in Neonatal Urinary Tract Infection"],"prefix":"10.1159","volume":"81","author":[{"given":"P.","family":"Bakakos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Messaritaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mandyla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Nicolaidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Anagnostakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,2,15]]},"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:52Z","timestamp":1745466592000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000047194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000047194","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2002]]}}}