{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:47:49Z","timestamp":1761580069682,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Infections and maternal smoking are risk factors for SIDS, and toxins from common bacteria have been proposed as a causative link between infections and SIDS. Nicotine can be transferred in significant amounts postnatally to the infant through environmental tobacco smoke or maternal smoking before nursing. We investigated the acute effects of nicotine and endotoxin on repeated apnea by laryngeal reflex stimulation and the following autoresuscitation. &lt;i&gt;Design:&lt;\/i&gt; Thirty-four 1-week-old (\u00b1 1 day) piglets were sedated and randomized to 1 of 4 pretreatment groups: (1)\u00a01\u00a0\u00b5g endotoxin i.v.\/kg; (2)\u00a05\u00a0\u00b5g nicotine i.v.\/kg; (3)\u00a01\u00a0\u00b5g endotoxin i.v.\/kg and 5\u00a0\u00b5g nicotine i.v.\/kg, and (4)\u00a0placebo. Apnea was induced by insufflation of 0.1\u00a0ml of acidified saline (pH 2) in the subglottic space of the trachea three times with intervals of 2\u00a0min. &lt;i&gt;Results:&lt;\/i&gt; Pretreatment with endotoxin caused a significant increase in plasma TNF-\u03b1 in the endotoxin groups (mean value \u00b1 SEM 953 \u00b1 246 and 980 \u00b1 226 pg\/ml, respectively) but no significant change in plasma IL-1\u03b2. Blood pressure, respiratory rate or S&lt;sub&gt;a&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt; was not significantly affected before induced apnea. Both pretreatment with nicotine and endotoxin caused prolonged apneas by 35\u201345%, a complete loss of normal hyperventilation during autoresuscitation, and prolonged hypoxia after apnea. &lt;i&gt;Conclusions:&lt;\/i&gt; Nicotine and endotoxin interferes with autoresuscitation after apnea. This experimental model on piglets may shed light over important mechanisms involved in the causation of SIDS.<\/jats:p>","DOI":"10.1159\/000047196","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"119-125","source":"Crossref","is-referenced-by-count":15,"title":["Prolonged Apneas and Hypoxia Mediated by Nicotine and Endotoxin in Piglets"],"prefix":"10.1159","volume":"81","author":[{"given":"J. Frederik","family":"Fr\u00f8en","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"Akre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babill","family":"Stray-Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(99)00082-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(99)00081-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(96)00051-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199703)55:3<177::AID-TERA2>3.0.CO;2-#"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90113-P"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(92)90131-A"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(85)90397-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90246-E"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00606-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91007-2"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:53Z","timestamp":1745466593000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000047196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000047196","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2002]]}}}