{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:28:13Z","timestamp":1785256093648,"version":"3.55.0"},"reference-count":2,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>A root dentin single\u2013section model was developed to compare the efficacy of different fluoride treatments on the remineralization of lesions. Shallow (\u223c170 \u00b5m) and deep (\u223c400 \u00b5m) lesions were produced in acetic acid buffer solutions (pH 5.0) with 0.1\u2013 and 0.5\u2013ppm fluoride for 3 days and 2 weeks, respectively. Next, the sections were pH\u2013cycled for 4 weeks. Following the pH cycling, all sections were first remineralized for 5 weeks, then subjected to 10 days of demineralization. The treatments were (1) no treatment (control), (2) daily 1,450\u2013ppm NaF toothpaste, (3) weekly 4,000\u2013ppm fluoride solution, (4) a combination of treatments 2 and 3. In the shallow lesions, the 4,000\u2013ppm fluoride solution and the combination treatment enhanced mineral deposition at the lesion front, producing a second, slightly hyperremineralized layer. Similarly, in the deep lesions a second remineralized layer was detected. In all lesions, the fluoride solution treatment showed significantly more remineralization compared to the control and the toothpaste treatment (p&lt;0.05), most of which was formed during the pH cycling. In the demineralization period, the control showed significantly higher mineral loss than all other treatments. These results indicate that a 4,000\u2013ppm fluoride solution might be effective for remineralization of root dentin lesions even over 400 \u00b5m depth.<\/jats:p>","DOI":"10.1159\/000047469","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"317-324","source":"Crossref","is-referenced-by-count":34,"title":["Effect of a Solution with High Fluoride Concentration on Remineralization of Shallow and Deep Root Surface Caries in vitro"],"prefix":"10.1159","volume":"35","author":[{"given":"Y.","family":"Mukai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Lagerweij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"ten Cate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,10,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000016476"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000016614"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/47469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:53:16Z","timestamp":1745466796000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000047469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":2,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2001,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000047469","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}