{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:57:41Z","timestamp":1789387061098,"version":"build-2803163510"},"reference-count":9,"publisher":"S. Karger AG","issue":"3-6","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiol Haemos Thromb"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Snake venom toxins are invaluable for the assay of coagulation factors and for the study of haemostasis generally. Thrombin-like enzymes (SVTLE) are used for fibrinogen and fibrinogen breakdown product assays as well as detecting dysfibrinogenaemias. Since SVTLE are not inhibited by heparin, they can be used for assaying antithrombin III in samples containing heparin. Snake venom prothrombin activators are utilised in prothrombin assays, whilst Russell\u2019s viper venom (RVV) can be used to assay clotting factors V, VII, X and lupus anticoagulants (LA). Activators from the taipan, Australian brown snake and saw-scaled viper have also been used to assay LA. Protein C (PC) and activated PC (APC) resistance can be measured by means of RVV, Protac&lt;sup&gt;TM&lt;\/sup&gt; (from Southern copperhead snake venom) and STA-Staclot (from &lt;i&gt;Crotalus viridis helleri&lt;\/i&gt;) whilst von Willebrand factor can be studied with Botrocetin&lt;sup&gt;TM&lt;\/sup&gt;&lt;i&gt;(Bothrops jararaca)&lt;\/i&gt;. Finally, snake venom C-type lectins and metalloproteinase disintegrins are being used to study platelet glycoprotein receptors and show great potential for use in the routine coagulation laboratory.<\/jats:p>","DOI":"10.1159\/000048065","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"211-217","source":"Crossref","is-referenced-by-count":10,"title":["Diagnostic Uses of Snake Venom"],"prefix":"10.1159","volume":"31","author":[{"given":"Neville A.","family":"Marsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2002,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(92)90023-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.14.8062"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.9.5200"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200012000-00011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(87)90253-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200007000-00008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0159"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(92)90040-C"}],"container-title":["Pathophysiology of Haemostasis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:59:42Z","timestamp":1745467182000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000048065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":9,"journal-issue":{"issue":"3-6","published-online":{"date-parts":[[2002,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000048065","archive":["Portico"],"relation":{},"ISSN":["1424-8832","1424-8840"],"issn-type":[{"value":"1424-8832","type":"print"},{"value":"1424-8840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}