{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:06:11Z","timestamp":1790201171891,"version":"4.1.0"},"reference-count":4,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background and Methods:&lt;\/i&gt; We compared the bacteriological, pharmacological and histopathological effects of parenterally administered ciprofloxacin (CPFX) to those of imipenem\/cilastatin (IMP\/CS) and cefozopran (CZOP) in a murine model of mucoid &lt;i&gt;Pseudomonas aeruginosa&lt;\/i&gt; pneumonia mimicking ventilator-associated pneumonia. &lt;i&gt;Results:&lt;\/i&gt; The minimum inhibitory concentrations (MICs) of CPFX, IMP and CZOP were 1.0, 1.0 and 4.0 mg\/l, respectively. Treatment with CPFX resulted in a significant decrease in the number of viable bacteria [control, IMP\/CS, CZOP and CPFX (mean \u00b1 SEM): 5.02 \u00b1 0.20, 4.96 \u00b1 0.38, 5.44 \u00b1 0.13 and 3.27 \u00b1 0.02 log&lt;sub&gt;10&lt;\/sub&gt; colony-forming units lung, respectively]. Histopathological examination revealed that inflammatory changes in the CPFX-treated group were less marked than in other groups. Of the drugs analyzed, the pharmacokinetic parameters of area under the time-concentration curve (AUC)\/MIC, AUC exceeding MIC and the time that lung concentrations of drug remained above the MIC were highest for CPFX. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results suggest that parenterally administered ciprofloxacin is effective in ventilator-associated &lt;i&gt;P. aeruginosa&lt;\/i&gt; pneumonia.<\/jats:p>","DOI":"10.1159\/000048553","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"421-429","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Parenterally Administered Ciprofloxacin in a Murine Model of Pulmonary &lt;i&gt;Pseudomonas aeruginosa&lt;\/i&gt; Infection Mimicking Ventilator-Associated Pneumonia"],"prefix":"10.1159","volume":"47","author":[{"given":"Yukihiro","family":"Kaneko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misuzu","family":"Kuroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Ohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kakeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Higashiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Hirakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Tomono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2002,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.2.462"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.1.200"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000007123"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(90)90093-B"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:05:07Z","timestamp":1745467507000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000048553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":4,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2001,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000048553","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}