{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:12:10Z","timestamp":1745554330458,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the role of serum troponin I (TnI) estimations in the early risk stratification of patients with acute coronary syndromes (ACS) subsequently diagnosed as acute myocardial infarction (AMI) or unstable angina (UA). &lt;i&gt;Subjects and Methods:&lt;\/i&gt; Blood samples were collected from 86 patients admitted to the Coronary Care Unit of the Mubarak Al-Kabeer Hospital, Kuwait, with a diagnosis of ACS on admission (TnI-1) and after 8\u00a0h (TnI-2) and 16\u00a0h (TnI-3). Blood was also collected from 38 age-matched healthy controls for comparison. Serum TnI was measured by paramagnetic particle chemiluminescent immunoassay. &lt;i&gt;Results:&lt;\/i&gt; Serum TnI of &lt;0.05 ng\/ml, corresponding to the 99th percentile, was established for healthy subjects. Patients diagnosed as UA had a 99th percentile TnI-1 value of about 0.30 ng\/ml. The best specificity and sensitivity for ACS was obtained for TnI-2; indeed, TnI-2 &gt;0.3 ng\/ml gave a &gt;80% certainty of diagnosis of AMI. Also, TnI-2 &lt;0.3 ng\/ml in ACS patients was approximately 80% sensitive for the diagnosis of UA but relatively nonspecific (approximately 40%). Specificity for TnI-2 for the diagnosis of UA improved to about 90% by narrowing the diagnostic range to 0.05\u20130.3 ng\/ ml. TnI values in UA increased by &lt;100% at 8\u00a0h, while in AMI, this increase was up to 1,000%. &lt;i&gt;Conclusion:&lt;\/i&gt; In the evaluation of ACS, admission and 8-hour serum TnI &lt;0.05 ng\/ml is probably not cardiac in origin; serum TnI &gt;0.3 ng\/ml on admission and increasing rapidly by 8\u00a0h is likely AMI, and serum TnI &gt;0.05 and &lt;0.3 ng\/ml on admission with a mild increase by 8\u00a0h is likely due to UA.<\/jats:p>","DOI":"10.1159\/000048655","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"18-22","source":"Crossref","is-referenced-by-count":3,"title":["Establishing a Gradient of Risk in Patients with Acute Coronary Syndromes Using Troponin I Measurements"],"prefix":"10.1159","volume":"11","author":[{"given":"Khalid","family":"Al-Harbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Zubaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abayomi O.","family":"Akanji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00804-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1258\/0004563001898989"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610313351801"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1986"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00943-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)10285-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905273402103"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1258\/0004563001900075"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7251.1702"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:05:55Z","timestamp":1745467555000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000048655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000048655","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2002]]}}}