{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:13:37Z","timestamp":1760782417035,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; It is well known that &lt;i&gt;Helicobacter pylori&lt;\/i&gt; changes its shapes according to various environmental conditions. The aim of this study was to examine the morphological differences between &lt;i&gt;H. pylori&lt;\/i&gt; in the duodenum and that in the stomach. &lt;i&gt;Methods:&lt;\/i&gt; Duodenal biopsy specimens were obtained from patients with duodenal mucosal lesions, and these specimens were then histopathologically examined. Morphological and genetic properties of cultured &lt;i&gt;H. pylori&lt;\/i&gt; isolates were analyzed. &lt;i&gt;Results:&lt;\/i&gt;&lt;i&gt;H. pylori&lt;\/i&gt; was identified in 16 out of 50 duodenal biopsy specimens. Along with the regular form, we found a fine form of &lt;i&gt;H. pylori&lt;\/i&gt; in the gastric metaplastic mucosa of ten duodenal specimens that was shorter in length and thinner in diameter than the regular helical form. There were no detectable differences between the &lt;i&gt;ureA-ureB&lt;\/i&gt; polymorphism of the duodenal fine form and that of gastric regular form in a single patient. As compared with patients without &lt;i&gt;H. pylori&lt;\/i&gt; in the duodenum, the prevalence of recurrent duodenal ulcers significantly increased in patients with the fine form (p &lt; 0.05), but not in patients with the regular form. &lt;i&gt;Conclusion:&lt;\/i&gt; The fine form of &lt;i&gt;H. pylori&lt;\/i&gt; in the metaplastic duodenal mucosa could result from its adaptation to the duodenal environment and may be associated with the recurrence of a duodenal ulcer.<\/jats:p>","DOI":"10.1159\/000048857","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"161-168","source":"Crossref","is-referenced-by-count":5,"title":["The Fine Form of &lt;i&gt;Helicobacter pylori&lt;\/i&gt; on the Metaplastic Duodenal Mucosa Is Associated with Recurrent Duodenal Ulcers"],"prefix":"10.1159","volume":"64","author":[{"given":"Shuichi","family":"Sano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Nishimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuhiro","family":"Kosaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomi","family":"Fujikawa-Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/41483"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:08:33Z","timestamp":1745467713000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000048857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":1,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000048857","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2001]]}}}