{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:26:23Z","timestamp":1761560783889,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; In developing countries the standard quadruple therapy containing metronidazole results in suboptimal eradication rates of &lt;i&gt;Helicobacter pylori&lt;\/i&gt; (&lt;75%). In a retrospective study, we undertook to evaluate efficacy and tolerability of a furazolidone-based regimen (omeprazole, furazolidone, bismuth, and tetracycline) in patients who had previously failed the standard metronidazole-based regimen (omeprazole, metronidazole, bismuth, and amoxicillin). &lt;i&gt;Methods:&lt;\/i&gt; The records of &lt;i&gt;H. pylori&lt;\/i&gt; infected patients who were referred to outpatient clinic (from March 1999 to August 1999) and who underwent previous eradication regimens were studied. A total of 320 cases were noted to have received a metronidazole-based quadruple regimen. From these 320 patients, 80 were noted to have failed this regimen based on a urea breath test. These 80 patients were enrolled in the study and given the furazolidone-based regimen. Side effects were assessed at follow-up visits. At least 2 months after the end of each therapy regimen, a &lt;sup&gt;14&lt;\/sup&gt;C-urea test was performed in each subject to document the cure of the patients. &lt;i&gt;Results:&lt;\/i&gt; A total of 80 patients (39 males and 41 females) with a mean age of 43.8 \u00b1 (SD) 13.3 years were studied. The &lt;i&gt;H. pylori&lt;\/i&gt; eradication rate was 90% with the furazolidone-based regimen. The side effects of this regimen were minor. &lt;i&gt;Conclusions:&lt;\/i&gt; A furazolidone-based regimen is effective in patients who do not achieve cure of &lt;i&gt;H. pylori&lt;\/i&gt; infection with the metronidazole-based quadruple therapy. In areas where the metronidazole resistance is high, initial therapy with a furazolidone-based regimen is recommended.<\/jats:p>","DOI":"10.1159\/000048865","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"222-225","source":"Crossref","is-referenced-by-count":26,"title":["Second-Line &lt;i&gt;Helicobacter pylori&lt;\/i&gt; Eradication with a Furazolidone-Based Regimen in Patients Who Have Failed a Metronidazole-Based Regimen"],"prefix":"10.1159","volume":"64","author":[{"given":"Rasoul","family":"Sotoudehmanesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Malekzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homayoon","family":"Vahedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser Ebrahimi","family":"Dariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Ali","family":"Asgari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadegh","family":"Massarrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.6.2.173"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:08:40Z","timestamp":1745467720000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000048865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":1,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000048865","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2001]]}}}