{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:50:30Z","timestamp":1760953830489,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Immunogenet"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Cutaneous T cell lymphomas (CTCLs) often show abnormal interleukin-2 (IL-2) receptor signaling. In this study, we investigated the role of Gab2, a recently identified adaptor molecule involved in IL-2 receptor signaling in CTCLs. We show that Gab2 was transiently phosphorylated by tyrosine in human mycosis fungoides (MF) tumor T cells upon IL-2 stimulation and that SHP2 as well as Stat5a associated inducibly with Gab2. IL-15, but not IL-4, also induced tyrosine phosphorylation of Gab2, suggesting that the IL-2 receptor \u03b2-chain is important for IL-2-induced Gab2 phosphorylation. Preincubation of cells with the Src family kinase inhibitor, PP1, surprisingly increased the IL-2- and IL-15-induced tyrosine phosphorylation of Gab2, indicating that an Src family kinase member negatively regulates IL-2 receptor signaling in MF T cells. Thus, although Gab2 seems to function normally in MF T cells compared to normal T cells, Gab2 itself might be abnormally regulated by an Src family kinase.<\/jats:p>","DOI":"10.1159\/000049187","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"86-95","source":"Crossref","is-referenced-by-count":13,"title":["Gab2 Is Phosphorylated on Tyrosine upon Interleukin-2\/Interleukin-15 Stimulation in Mycosis-fungoides-Derived Tumor T Cells and Associates Inducibly with SHP-2 and Stat5a"],"prefix":"10.1159","volume":"18","author":[{"given":"Johannes Lundin","family":"Brockdorff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Mustelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keld","family":"Kaltoft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Geisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"R\u00f6pke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"\u00d8dum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9148"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199802000-00001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.132.5.554"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.13.6764"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.6959"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(99)00016-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.1.599"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3845"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.19.10620"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.26.16421"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.29.18273"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.35.24469"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.28.19649"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(200001)30:01<59::AID-IMMU59>3.3.CO;2-E"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.3.515"}],"container-title":["Experimental and Clinical Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:12:22Z","timestamp":1745467942000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000049187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000049187","archive":["Portico"],"relation":{},"ISSN":["0254-9670","1421-9948"],"issn-type":[{"type":"print","value":"0254-9670"},{"type":"electronic","value":"1421-9948"}],"subject":[],"published":{"date-parts":[[2001]]}}}