{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:12:42Z","timestamp":1745554362074,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The role of 5-lipoxygenase (5-LO) products in the asthmatic bronchoconstriction is evident. However, the role of 5-LO products in airway hyperresponsiveness (AHR) and airway inflammation is still under discussion. The aim of the present study is to investigate the role of leukotriene D&lt;sub&gt;4&lt;\/sub&gt; (LTD&lt;sub&gt;4&lt;\/sub&gt;) in AHR and allergic airway eosinophilia in mice. &lt;i&gt;Methods:&lt;\/i&gt; The effect of LTD&lt;sub&gt;4&lt;\/sub&gt; inhalation on antigen-induced AHR and airway eosinophilia was investigated in 5-LO gene-deficient mice. &lt;i&gt;Results:&lt;\/i&gt; After three inhalations of LTD&lt;sub&gt;4&lt;\/sub&gt;, airway responsiveness to acetylcholine was not altered in normal or allergic wild-type and 5-LO knockout (KO) mice. In contrast, the number of eosinophils in 5-LO KO allergic mice increased to the level of wild-type allergic mice after the inhalation of LTD&lt;sub&gt;4&lt;\/sub&gt;. These observations were confirmed by a histopathological study of the lungs. No change in the cytokine levels in bronchoalveolar lavage fluid and serum immunoglobulin levels was shown after LTD&lt;sub&gt;4&lt;\/sub&gt; inhalation. &lt;i&gt;Conclusion:&lt;\/i&gt; These findings suggest that LTD&lt;sub&gt;4&lt;\/sub&gt; plays a role in eosinophilic airway inflammation but not in AHR in mice.<\/jats:p>","DOI":"10.1159\/000049528","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"309-317","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Leukotriene D&lt;sub&gt;4&lt;\/sub&gt; Inhalation on the Antigen-Induced Airway Hyperresponsiveness and Inflammation in 5-Lipoxygenase Gene-Deficient Mice"],"prefix":"10.1159","volume":"126","author":[{"given":"Naoki","family":"Kawada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouta","family":"Tokuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisei","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroichi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.3.1.59"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(98)00081-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.11.1213"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1063"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000024002"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:16:20Z","timestamp":1745468180000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000049528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000049528","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2001]]}}}