{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:05:20Z","timestamp":1788973520259,"version":"build-2803163510"},"reference-count":3,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Peripheral tissue oxygen utilization was studied during hypoxic-induced acidosis and sodium bicarbonate-induced alkalosis in 8 domestic pigs by measurements of subcutaneous oxygen tension (P&lt;sub&gt;sc&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt;), carbon dioxide tension (P&lt;sub&gt;sc&lt;\/sub&gt;CO&lt;sub&gt;2&lt;\/sub&gt;) and pH (pH&lt;sub&gt;sc&lt;\/sub&gt;) in relation to central hemodynamic parameters and oxygenation. Hypoxic-induced acidosis resulted in a decrease in P&lt;sub&gt;sc&lt;\/sub&gt;CO&lt;sub&gt;2&lt;\/sub&gt; and arterial oxygen tension (P&lt;sub&gt;a&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt;) to one third of baseline values (p &lt; 0.05), an increase in P&lt;sub&gt;sc&lt;\/sub&gt;CO&lt;sub&gt;2&lt;\/sub&gt; and arterial carbon dioxide tension (P&lt;sub&gt;a&lt;\/sub&gt;CO&lt;sub&gt;2&lt;\/sub&gt;) from 41 to 55 and 34 to 39\u00a0mm Hg, respectively (p &lt; 0.05), and a decrease in pH&lt;sub&gt;sc&lt;\/sub&gt; from 7.47 to 7.30 (p &lt; 0.05). P&lt;sub&gt;sc&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt; and P&lt;sub&gt;a&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt; increased during reversal of hypoxia and infusion of bicarbonate (p &lt; 0.05), without reaching baseline values. In parallel P&lt;sub&gt;sc&lt;\/sub&gt;CO&lt;sub&gt;2&lt;\/sub&gt; decreased and pH&lt;sub&gt;sc&lt;\/sub&gt; increased but changes lagged behind changes in blood gases. Alkalosis established by further infusion of bicarbonate resulted in a decrease in P&lt;sub&gt;a&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt; to 62\u00a0mm Hg whereas P&lt;sub&gt;sc&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt; remained below baseline values (p &lt; 0.05). Correction of oxygen utilization in the subcutaneous tissue as measured by the markers P&lt;sub&gt;sc&lt;\/sub&gt;CO&lt;sub&gt;2&lt;\/sub&gt; and pH&lt;sub&gt;sc&lt;\/sub&gt; is slower than indicated by changes in tissue oxygen tension, blood gases and pH. Overcompensation of acidosis with bicarbonate resulting in alkalosis impairs oxygenation.<\/jats:p>","DOI":"10.1159\/000049696","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"64-70","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Subcutaneous Tissue Gases and pH during Induction of Acidosis and Alkalosis"],"prefix":"10.1159","volume":"33","author":[{"given":"\u00c5.","family":"Mellstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Jedlinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"J\u00f6nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000008710"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/00365519850186841"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000008769"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:18:11Z","timestamp":1745468291000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000049696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":3,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000049696","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}