{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:50:55Z","timestamp":1776487855771,"version":"3.51.2"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; Data are inconsistent whether hyperinsulinemia might be associated with adrenal hyperandrogenism in young adults born with low birth weight (LBW). &lt;i&gt;Method:&lt;\/i&gt; We investigated the insulin and adrenal steroid production of 70 young LBW adults [33 women (birth weight: 1,795 \u00b1 435 g) and 37 men (birth weight: 1,832 \u00b1 337 g)]. Their results were compared to those of 30 controls (14 men, 16 women), born with normal weight. &lt;i&gt;Results:&lt;\/i&gt; In LBW women, we measured higher basal DHEA (33.5 \u00b1 13.1 vs. 23.6 \u00b1 8.7 nmol\/l, p &lt; 0.05), DHEAS (8.0 \u00b1 2.3 vs. 6.3 \u00b1 2.1 \u00b5mol\/l, p &lt; 0.05), androstenedione (8.3 \u00b1 2.8 vs. 6.0 \u00b1 2.2 nmol\/l, p &lt; 0.05) and cortisol (0.25 \u00b1 0.07 vs. 0.20 \u00b1 0.07 \u00b5mol\/l, p &lt; 0.05) levels and higher insulin response during oral glucose tolerance test (log.AUCins: 2.62 \u00b1 0.06 vs. 2.57 \u00b1 0.03, p &lt; 0.05). DHEA levels correlated with fasting insulin levels (r = 0.45, p &lt; 0.01) and insulin response (r = 0.33, p &lt; 0.05). In LBW men, higher cortisol (0.27 \u00b1 0.06 vs. 0.22 \u00b1 0.06 \u00b5mol\/l, p &lt; 0.01) and SHBG (18.4 \u00b1 10.4 vs. 12.7 \u00b1 5.9 nmol\/l, p &lt; 0.05) levels were found. &lt;i&gt;Conclusions:&lt;\/i&gt; Our results suggest that modest hypercortisolism is present in young LBW adults. While the endocrine sequel of hypercortisolism raised insulin response and hyperandrogenism is detectable in apparently healthy young LBW women, it is absent in young LBW men. This suggests that gender-dependent mechanisms might play a role in the development of insulin resistance in LBW adults.<\/jats:p>","DOI":"10.1159\/000049991","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"172-178","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Low Birth Weight on Adrenal Steroids and Carbohydrate Metabolism in Early Adulthood"],"prefix":"10.1159","volume":"55","author":[{"given":"Mikl\u00f3s","family":"Szathm\u00e1ri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barna","family":"V\u00e1s\u00e1rhelyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tivadar","family":"Tulassay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91224-A"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.11.3945"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4739"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000023377"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02384-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/er.16.3.322"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90148-A"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604113341504"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.3.757"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00864.x"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/49991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:19:08Z","timestamp":1745468348000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000049991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000049991","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}