{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:40:34Z","timestamp":1777920034260,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; This prospective study of children undergoing major craniofacial surgery was undertaken to determine whether abnormal hemostasis occurred and to characterize any coagulopathy found. &lt;i&gt;Methods:&lt;\/i&gt; Coagulation tests, blood loss and blood product transfusions were recorded perioperatively. Packed red blood cells (PRBC) were transfused to maintain target hematocrit. Patients with blood loss &gt;100\u00a0ml\/kg (group A, n = 5) were compared to patients with blood loss &lt;100\u00a0ml\/kg (group B, n = 22) using Mann-Whitney U test (p &lt; 0.05). &lt;i&gt;Results:&lt;\/i&gt; Twenty-seven children (age range 2.9\u201327.9 months) had median total blood loss of 64\u00a0ml\/kg. At completion of surgery, median coagulation values differed significantly between groups for prothrombin time (A: 16.6\u00a0s; B: 13.8\u00a0s), partial thromboplastin time (A: 44\u00a0s; B: 29\u00a0s), thrombin time (A: 28\u00a0s; B: 23\u00a0s), thromboelastograph reaction time (A: 7\u00a0mm; B: 4\u00a0mm), prothrombin fragment F1.2 (A: 1.9\u00a0nmol\/l; B: 3.3\u00a0nmol\/l) and platelet count (A: 174\u00a0K\/mm&lt;sup&gt;\u20133&lt;\/sup&gt;; B: 239\u00a0K\/mm&lt;sup&gt;\u20133&lt;\/sup&gt;). Fibrinolysis was not associated with blood loss. Median units transfused were in group A 3 units and group B 1 unit (p = 0.001). All patients received PRBC transfusions but only group A patients received other blood products (fresh frozen plasma, platelets). &lt;i&gt;Conclusion:&lt;\/i&gt; Children transfused with PRBC during craniosynostosis repair can become coagulopathic from coagulation factor depletion when hemorrhage approaches 1.5 times estimated blood volume.<\/jats:p>","DOI":"10.1159\/000050378","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"5-12","source":"Crossref","is-referenced-by-count":43,"title":["Abnormal Coagulation during Pediatric Craniofacial Surgery"],"prefix":"10.1159","volume":"35","author":[{"given":"Glyn D.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard G.","family":"Ellenbogen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph S.","family":"Gruss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,7,27]]},"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:23:38Z","timestamp":1745468618000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000050378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000050378","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"value":"1016-2291","type":"print"},{"value":"1423-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}