{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:54:08Z","timestamp":1761486848938,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Multidrug-resistant pulmonary tuberculosis (MDRTB), a major problem in developing countries, may result from either insufficiency of host cellular immune response or mycobacterial mechanisms which has been more intensively investigated so far. &lt;i&gt;Objectives:&lt;\/i&gt; The aim of the study was to investigate natural killer cell activity (NKA) and T lymphocyte subsets in HIV\u2013 patients with secondary MDRTB. &lt;i&gt;Methods:&lt;\/i&gt; 20 male patients with MDRTB (mean age 38 \u00b1 8 years), 15 nonresistant tuberculosis male patients (NRTB) (mean age 36 \u00b1 11 years) and 12 healthy male controls (mean age 35 \u00b1 8 years) were included. The percentages of CD3+, CD4+, CD8+, CD25+, CD11b+ and CD16+56+ cells were measured by flow-cytometric analysis of peripheral blood lymphocytes (PBL). NKA was evaluated using the anticandidal index method. &lt;i&gt;Results:&lt;\/i&gt; The mean tuberculin response was higher in MDRTB and NRTB patients compared to controls (15.4 \u00b1 3.8, 15.1 \u00b1 3.3 and 10.9 \u00b1 2.8 mm, respectively; p &lt; 0.001). There was no significant correlation between PPD response and PBL subsets or NKA. The percentages of both CD3+ and CD3+CD4+ T lymphocytes were significantly lower in MDRTB (62.4 \u00b1 12.1 and 33.9 \u00b1 9.0%) compared to NRTB (70.8 \u00b1 7.5 and 42.9 \u00b1 8.6%; p &lt; 0.05). Patients with MDRTB had significantly lower NKA compared to NRTB and controls (30.9 \u00b1 11.3, 49.7 \u00b1 15.5 and 40.0 \u00b1 8.5%, respectively; p &lt; 0.01). &lt;i&gt;Conclusion:&lt;\/i&gt; This reduction in NKA may suggest a role for impaired NK function in the pathogenesis of MDRTB in HIV\u2013 patients.<\/jats:p>","DOI":"10.1159\/000050577","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"590-594","source":"Crossref","is-referenced-by-count":6,"title":["Natural Killer Cell Activity in Multidrug-Resistant Pulmonary Tuberculosis"],"prefix":"10.1159","volume":"68","author":[{"given":"P\u0131nar","family":"Yildiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Kadakal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u0131ld\u0131z","family":"T\u00fct\u00fcnc\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnnur","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"G\u00fcrel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan","family":"Ad\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veysel","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,12,21]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:56:25Z","timestamp":1745466985000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000050577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2001,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000050577","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2001]]}}}