{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:42:40Z","timestamp":1768340560634,"version":"3.49.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>The majority of pancreatic neoplasms show a ductal phenotype and can be classified as ductal adenocarcinomas. Pancreatic duct lesions have been discussed as tumor precursors. This review presents a recently adopted standard system for these lesions which distinguishes among three grades of pancreatic intraepithelial neoplasia (PanIN). Molecular studies revealed that PanIN-2 and PanIN-3 lesions represent a distinct step towards invasive carcinoma. Another focus of the review is the advances that have been made in the further immunohistochemical and molecular characterization of special pancreatic neoplasms showing a ductal phenotype, such as undifferentiated carcinoma, mucinous noncystic (colloid) carcinoma, intraductal papillary mucinous neoplasm, mucinous cystic neoplasm, medullary carcinoma, and other rare tumors.<\/jats:p>","DOI":"10.1159\/000050649","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"15-23","source":"Crossref","is-referenced-by-count":23,"title":["Update on the Pathology and Genetics of Exocrine Pancreatic Tumors with Ductal Phenotype: Precursor Lesions and New Tumor Entities"],"prefix":"10.1159","volume":"19","author":[{"given":"J.","family":"L\u00fcttges","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kl\u00f6ppel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199802000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980215)82:4<651::AID-CNCR6>3.3.CO;2-I"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1703::AID-CNCR9>3.3.CO;2-I"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050428"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2352::AID-CNCR9>3.3.CO;2-Z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1279::AID-CNCR10>3.3.CO;2-H"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199805)185:1<53::AID-PATH45>3.0.CO;2-F"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.18491"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199810000-00010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200101000-00003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200010000-00006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010101)91:1<35::AID-CNCR5>3.0.CO;2-A"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.8442"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199610)180:2<160::AID-PATH625>3.0.CO;2-A"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199608000-00007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199904000-00005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199910000-00006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200011000-00011"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200004000-00003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050447"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:56:32Z","timestamp":1745466992000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000050649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000050649","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}