{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:19:36Z","timestamp":1773026376760,"version":"3.50.1"},"reference-count":4,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2001]]},"abstract":"<i>Introduction\/Objective:<\/i> N-acetyltransferase 2 <i>(NAT2),<\/i> mapped to 8p22, is a polymorphic enzyme which metabolizes aromatic amines. Loss of heterozygosity of 8p22 is associated with an increased risk of bladder cancer. This study evaluated <i>NAT2<\/i> and chromosome 8 in sequential tumours from bladder cancer patients to determine if <i>NAT2<\/i> alterations increase the risk of progression. <i>Materials and Methods:<\/i> Thirty-seven sequential carcinomas from 19 patients were assessed using fluorescence in situ hybridization. <i>Results:<\/i> Five carcinomas showed loss of <i>NAT2;<\/i> 4 of these were from pTa\/pT1 tumours. Polysomy 8 was observed in 4 of 14 (29%) primary carcinomas (pTa\/pT1), in 4 of 12 (33%) pTa\/pT1 recurrences, and in 90% (9\/10) of the detrusor muscle invasive tumours (pT2+). 6 of 8 (75%) locally invasive tumours with polysomy 8 were from patients who subsequently developed disease progression (pT2+). In total, 13.5% (5\/37) of the carcinomas were abnormal for <i>NAT2,<\/i> and 46% (17\/37) were abnormal for chromosome 8 copy number. Polysomy 8 was associated with high grade (p = 0.01) and stage (p = 0.03) and disease progression (p = 0.03). <i>Conclusion:<\/i> Whilst there does not appear to be an association between loss of <i>NAT2<\/i> and risk of progression in transitional cell carcinoma, the high rate of polysomy of chromosome 8 implies that other genes on this chromosome significantly influence disease progression.<\/jats:p>","DOI":"10.1159\/000050995","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"235-239","source":"Crossref","is-referenced-by-count":6,"title":["Genetic Aberrations of <i>NAT2<\/i> and Chromosome 8: Their Association with Progression in Transitional Cell Carcinoma of the Urinary Bladder"],"prefix":"10.1159","volume":"67","author":[{"given":"A.D.","family":"Watters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.W.","family":"Stacey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Going","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Grigor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.G.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.S.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2000.00326.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<376::AID-GCC10>3.3.CO;2-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199905)25:1<1::AID-GCC1>3.0.CO;2-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990420)84:2<169::AID-IJC13>3.3.CO;2-6"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/50995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:00:40Z","timestamp":1745467240000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000050995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":4,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000050995","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}