{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:15:27Z","timestamp":1791126927716,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Cerebrospinal fluid (CSF) levels of tau (total tau), growth-associated protein-43 (GAP-43), soluble amyloid precursor protein (sAPP; i.e. total sAPP), and \u03b2-amyloid&lt;sub&gt;42&lt;\/sub&gt; (A\u03b2&lt;sub&gt;42&lt;\/sub&gt;) were studied in patients with frontotemporal dementia (FTD; n = 14), Alzheimer\u2019s disease (AD; n = 47) and vascular dementia (VAD; n = 16), and in age-matched controls (n = 12). CSF-tau was increased in AD compared to controls and FTD (p &lt; 0.001 for both). CSF-GAP-43 was increased in AD compared to controls (p &lt; 0.05), and both CSF-GAP-43 and CSF-sAPP were increased in AD compared to FTD (p &lt; 0.01). Positive and highly significant correlations were found between CSF-tau and CSF-GAP-43 in all groups and between CSF-tau, CSF-GAP-43 and CSF-sAPP in AD. The correlations found may reflect a common pathophysiologic process such as axonal degeneration.<\/jats:p>","DOI":"10.1159\/000051268","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"257-264","source":"Crossref","is-referenced-by-count":107,"title":["The Cerebrospinal Fluid Levels of Tau, Growth-Associated Protein-43 and Soluble Amyloid Precursor Protein Correlate in Alzheimer\u2019s Disease, Reflecting a Common Pathophysiological Process"],"prefix":"10.1159","volume":"12","author":[{"given":"Magnus","family":"Sj\u00f6gren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Davidsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Gottfries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Vanderstichele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Edman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeen","family":"Vanmechelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020070079"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000007917"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199706)12:6<656::AID-GPS593>3.0.CO;2-L"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000007917"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90078-Z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91532-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.13.7640"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90582-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91329-D"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90767-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199908)46:2<243::AID-ANA14>3.0.CO;2-L"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13266"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.47.1.387"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:03:29Z","timestamp":1745467409000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000051268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000051268","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}