{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:59:43Z","timestamp":1777946383655,"version":"3.51.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Bcl-2 expression in leukocytes plays an important role in autoimmune and inflammatory disease. &lt;i&gt;Objective:&lt;\/i&gt; In the present study, we investigated the Bcl-2 expression in the skin pathergy reaction (SPR) of Beh\u00e7et\u2019s disease (BD). &lt;i&gt;Methods:&lt;\/i&gt; The skin pathergy test (SPT) was performed on 23 patients with BD and 7 healthy controls. After 48 h, SPT specimens were taken by punch biopsy. Control samples were also obtained from the normal skin of 7 patients with BD and 11 patients with BD-unrelated leukocytoclastic vasculitis. Biopsy specimens were evaluated by routine histopathological examination and immunohistochemical Bcl-2 staining. &lt;i&gt;Results:&lt;\/i&gt; The SPT was clinically positive in 9 of 23 patients and histopathologically positive in 13 but never in the healthy controls. The majority of leukocytes in 12 of 13 histopathologically positive specimens were stained with Bcl-2. Only 3 BD-unrelated leukocytoclastic vasculitis samples showed Bcl-2 positivity. No Bcl-2 staining was found in healthy controls and normal skin samples of patients with BD. &lt;i&gt;Conclusion:&lt;\/i&gt; Our data may suggest a role of Bcl-2-mediated inflammation in the pathogenesis of the SPR in BD.<\/jats:p>","DOI":"10.1159\/000051605","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"90-93","source":"Crossref","is-referenced-by-count":4,"title":["Bcl-2 Expression in Skin Pathergy Reaction of Beh\u00e7et\u2019s Disease"],"prefix":"10.1159","volume":"202","author":[{"given":"Yuksel","family":"Sullu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilgun","family":"Senturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurdanur Demirel","family":"Sullu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Yasar","family":"Turanli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92643-V"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1994.1176"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/348334a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199804)41:4<596::AID-ART6>3.3.CO;2-U"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:07:06Z","timestamp":1745467626000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000051605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000051605","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}