{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:10:24Z","timestamp":1776082224950,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background and Objective: &lt;\/i&gt;Acne in women can often be successfully treated by the intake of oral contraceptives containing gestagens with anti-androgenic properties. This study aimed to evaluate the efficacy of the monophasic oral contraceptive ethinylestradiol\/chlormadinone acetate (EE\/CMA; Belara&lt;sup&gt;\u00ae&lt;\/sup&gt;) for the treatment of mild to moderate papulopustular acne of the face and acne-related disorders in comparison to EE\/levonorgestrel (LNG; Microgynon&lt;sup&gt;\u00ae&lt;\/sup&gt;). &lt;i&gt;Methods:&lt;\/i&gt; 199 female acne patients were enrolled in a single-blind, randomized, multicentre phase III study and divided into two groups who received either EE\/CMA or EE\/LNG. The primary end point was fulfilled if the number of papules\/pustules per half of the face present on admission had decreased by at least 50% in the 12th medication cycle. &lt;i&gt;Results:&lt;\/i&gt; 59.4% of the women under EE\/CMA and 45.9% under EE\/LNG were responders. The relative frequency of women with complete resolution was 16.5% under EE\/CMA and 4.3% under EE\/LNG at cycle 12.&lt;sup&gt;&lt;\/sup&gt;&lt;i&gt;Conclusion:&lt;\/i&gt; EE\/CMA&lt;sup&gt;&lt;\/sup&gt;is an efficient treatment for women with mild and moderate papulopustular acne of the face and related disorders, reflecting the well-known anti-androgenic properties of the progestogen CMA.<\/jats:p>","DOI":"10.1159\/000051701","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"38-44","source":"Crossref","is-referenced-by-count":69,"title":["Acne Resolution Rates: Results of a Single-Blind, Randomized, Controlled, Parallel Phase III Trial with EE\/CMA (Belara&lt;sup&gt;\u00ae&lt;\/sup&gt;) and EE\/LNG (Microgynon&lt;sup&gt;\u00ae&lt;\/sup&gt;)"],"prefix":"10.1159","volume":"203","author":[{"given":"I.","family":"Worret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Arp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-P.","family":"Zahradnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-O.","family":"Andreas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,9,3]]},"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:08:44Z","timestamp":1745467724000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000051701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000051701","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}