{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:56:59Z","timestamp":1790848619398,"version":"4.1.0"},"reference-count":7,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Recent evidence indicates that acute stress can precipitate a number of dermatological conditions, including alopecia areata. This effect may be mediated by corticotropin-releasing hormone (CRH) released locally in the skin from dorsal root ganglia or immune cells. CRH typically acts through activation of specific receptors that are either type 1 or types 2\u03b1 and 2\u03b2. CRH, or related peptides such as urocortin, could have proinflammatory effects directly or through activation of mast cells leading to destruction of the hair root. &lt;i&gt;Objectives:&lt;\/i&gt; To investigate the expression of CRH receptors on the affected skin of patients who developed alopecia areata following acute emotional stress. &lt;i&gt;Methods:&lt;\/i&gt; Scalp skin biopsies were obtained from 1 normal volunteer and 3 patients after ring infiltration of the relevant site with lidocaine. The biopsies were frozen and were later processed for in situ hybridization for CRH receptors type 1 or types 2\u03b1 and 2\u03b2. Sections showing positive results were photographed. &lt;i&gt;Results:&lt;\/i&gt; The skin from the normal volunteer showed weak background expression of all three receptor types. However, skin from the affected sites of all 3 patients studied showed intense expression only on the type 2\u03b2 receptor around the hair follicles. &lt;i&gt;Conclusion:&lt;\/i&gt; Acute emotional stress may precipitate alopecia areata by activation of overexpressed type 2\u03b2 CRH receptors around the hair follicles leading to intense local inflammation.<\/jats:p>","DOI":"10.1159\/000051732","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"157-161","source":"Crossref","is-referenced-by-count":83,"title":["Alopecia areata and Affected Skin CRH Receptor Upregulation Induced by Acute Emotional Stress"],"prefix":"10.1159","volume":"203","author":[{"given":"Alexandra","family":"Katsarou-Katsari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theoharis C.","family":"Theoharides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750042826"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310213291708"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.9.4139"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/en.139.1.403"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750010238"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750010706"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:09:04Z","timestamp":1745467744000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000051732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000051732","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}