{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:23:48Z","timestamp":1759638228025,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; There are no published studies of the effect of methylrosaniline chloride (MRC) on inflammation when used at the concentration recommended in the &lt;i&gt;New German Formulary&lt;\/i&gt;. A tissue-damaging effect has been described in animal studies and at higher concentrations in humans. &lt;i&gt;Objective:&lt;\/i&gt; To determine whether 0.5% MRC increases or reduces skin damage in irritative dermatitis. &lt;i&gt;Methods:&lt;\/i&gt; The study was carried out on the sodium lauryl sulfate (SLS) skin irritation model in 18 healthy volunteers. The impact of intermittent treatment with 0.5% MRC or drug-free vehicle on three SLS exposure effects was determined: reduction of stratum corneum water content (corneometry), increase in subpapillary blood flow (laser Doppler method) and barrier damage (transepidermal water loss). &lt;i&gt;Results:&lt;\/i&gt; MRC produced significant reductions in all three SLS exposure effects. &lt;i&gt;Conclusions:&lt;\/i&gt; Treatment of irritative dermatitis with 0.5% MRC is expected to produce a high clinical efficacy not only because of the compound\u2019s established antimicrobial activity, but also because of its anti-irritative effect.<\/jats:p>","DOI":"10.1159\/000051782","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"325-328","source":"Crossref","is-referenced-by-count":6,"title":["Anti-Irritative Effect of Methylrosaniline Chloride (Gentian Violet)"],"prefix":"10.1159","volume":"203","author":[{"given":"Max","family":"Gloor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Wolnicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000018253"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:09:42Z","timestamp":1745467782000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000051782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":1,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000051782","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2001]]}}}