{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:56:44Z","timestamp":1761893804257,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>&lt;i&gt;Pit&lt;\/i&gt;-1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals. My laboratory and others have recently described several patients with combined pituitary hormone deficiency (CPHD) due to point mutations in the &lt;i&gt;pit&lt;\/i&gt;-1 gene. In addition to &lt;i&gt;pit&lt;\/i&gt;-1, other nuclear factors appear to be necessary for full expression of pituitary genes. A zinc finger transcription factor, Zn-15, is responsible with &lt;i&gt;pit&lt;\/i&gt;-1 for synergistic activation of the GH gene. The Prl gene is regulated synergistically by &lt;i&gt;pit&lt;\/i&gt;-1 and the estrogen receptor. Finally, the &lt;i&gt;pit&lt;\/i&gt;-1 gene itself is regulated by an enhancer element located &gt;10 kb upstream of the transcriptional start. This element contains several &lt;i&gt;pit&lt;\/i&gt;-1 DNA binding sites and retinoic acid response elements (RAREs). On one of these elements, &lt;i&gt;pit&lt;\/i&gt;-1 and RAR interact functionally to mediate a synergistic response to RA. Recent data from our laboratory suggests that RA induction of the &lt;i&gt;pit&lt;\/i&gt;-1 gene can be impaired by &lt;i&gt;pit&lt;\/i&gt;-1 gene mutations. Study of &lt;i&gt;pit&lt;\/i&gt;-1 mutations and their diverse pathophysiological mechanisms should increase our understanding of anterior pituitary gland development and gene regulation in normal and disease states.<\/jats:p>","DOI":"10.1159\/000053065","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"30-36","source":"Crossref","is-referenced-by-count":16,"title":["The Molecular Basis of Hypopituitarism"],"prefix":"10.1159","volume":"49","author":[{"given":"Sally","family":"Radovick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie E.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredric E.","family":"Wondisford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90038-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90067-O"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/347528a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/345829a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/347528a0"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:19:23Z","timestamp":1745468363000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000053065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":5,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[1998,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000053065","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[1998]]}}}