{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:12:09Z","timestamp":1758820329707,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"1-3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; It is well recognized that CD8 T cells inhibit IgE responses. In this study, we investigated the mechanism of CD8 T cell-mediated IgE suppression by comparing the capacity of T cytotoxic 1 (Tc1) and T cytotoxic 2 (Tc2) CD8 T cells to inhibit IgE responses to ovalbumin (OVA). &lt;i&gt;Methods:&lt;\/i&gt; Tc1 and Tc2 CD8 T cells were generated from OVA&lt;sup&gt;257\u2013264&lt;\/sup&gt;-specific V\u03b25.2 T cell receptor (TcR) transgenic mice by stimulation with anti-CD3 and anti-CD28 under Tc1 and Tc2 polarizing conditions. Tc1 and Tc2 V\u03b25.2 TcR CD8 T cells (10&lt;sup&gt;6&lt;\/sup&gt;) were adoptively transferred to syngeneic mice, and following immunization with 100 \u00b5g of OVA\/alum, serum IgE antibodies were measured by passive cutaneous anaphylaxis and expressed as the highest dilution that gave a detectable skin response. &lt;i&gt;Results:&lt;\/i&gt; Both Tc1 and Tc2 CD8 T cells from OT-I mice inhibited IgE. &lt;i&gt;Conclusion:&lt;\/i&gt; Both Tc1 and Tc2 CD8 T cells promote Th1 immunity and inhibit IgE responses. This process appears to be independent of CD8 T cell-derived IFN-\u03b3, as both Tc2 (IFN-\u03b3\u2013) and Tc1 (IFN-\u03b3+) CD8 T cells inhibited IgE.<\/jats:p>","DOI":"10.1159\/000053706","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"187-189","source":"Crossref","is-referenced-by-count":18,"title":["T Cytotoxic 1 and T Cytotoxic 2 CD8 T Cells Both Inhibit IgE Responses"],"prefix":"10.1159","volume":"124","author":[{"given":"Matthew J.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"MacAry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair","family":"Noble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip W.","family":"Askenase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Kemeny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,1,24]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1038\/39614"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016\/S0167-5699(97)01000-1"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1159\/000024103"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:26:44Z","timestamp":1745468804000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000053706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":3,"journal-issue":{"issue":"1-3","published-online":{"date-parts":[[2001,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000053706","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2001]]}}}