{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:06:45Z","timestamp":1760170005917,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Despite our knowledge that maternal inheritance influences the development of asthma in childhood, attempts to identify a clear-cut Th2-oriented cytokine production by T lymphocytes at birth have given conflicting results. The prognostic significance of these cells for asthma development later in life remains to be determined. &lt;i&gt;Methods:&lt;\/i&gt; We evaluated at the single cell level Th1- and Th2-type cytokines in 208 randomly selected cord blood mononuclear cell (CBMC) samples obtained from pregnant women (group A, n = 68 with diagnosed respiratory allergic disease; group B, n = 140, with no evidence of atopy), and prospectively followed newborns for 1 year. &lt;i&gt;Results:&lt;\/i&gt; There was no difference in IFN-\u03b3, IL-4 and IL-5 production at birth between both groups, whereas a correlation between CD4+IL13+ lymphocytes from CBMC samples derived from atopic mothers and the occurrence of wheezing and\/or asthma during the 1st year of life was found. &lt;i&gt;Conclusions:&lt;\/i&gt; Our observations suggest that the intracellular cytokine profile of cord blood CD4+ cells, in terms of IL-13 production, could be considered a useful tool for a more accurate identification of newborns from atopic mothers who are at high risk of developing asthma.<\/jats:p>","DOI":"10.1159\/000053785","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"497-501","source":"Crossref","is-referenced-by-count":24,"title":["CD4+IL13+ T Lymphocytes at Birth and the Development of Wheezing and\/or Asthma during the 1st Year of Life"],"prefix":"10.1159","volume":"124","author":[{"given":"Fabrizio","family":"Spinozzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Agea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Russano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onelia","family":"Bistoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Minelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Bologni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Bertotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando M.","family":"de Benedictis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.12.1.295"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01548-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(93)90158-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.12.1.635"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1285"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.12.1.227"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03975-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.255"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1344"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05104-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2261"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80439-2"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:27:51Z","timestamp":1745468871000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000053785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000053785","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2001]]}}}