{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:03Z","timestamp":1745554383028,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Asthma is characterized by airway inflammation with prominent eosinophil infiltrates. In a murine model of asthma, antigen-induced eosinophil recruitment into the airways of sensitized mice is mediated by CD4+ T cells and their cytokines, especially IL-5. In the present study, using ovalbumin-specific T cell receptor transgenic mice, we found that T cell vaccination, which was the administration of preactivated and attenuated antigen-specific T cells by the intraperitoneal route, prevented antigen-induced eosinophil recruitment into the airways. This effect was antigen-specific because ovalbumin-specific T cell vaccination did not affect BSA-induced eosinophil recruitment into the airways. We also found that antigen-specific IgE production as well as antigen-induced proliferation and cytokine production of splenocytes were diminished by T cell vaccination. Moreover, flow-cytometric analyses revealed that T cell vaccination eliminated antigen-specific T cells in the periphery. Together, these results indicate that T cell vaccination prevents antigen-induced eosinophil recruitment into the airways presumably by eliminating antigen-specific T cells.<\/jats:p>","DOI":"10.1159\/000053856","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"59-66","source":"Crossref","is-referenced-by-count":1,"title":["T Cell Vaccination Eliminates Antigen-Specific T Cells and Prevents Antigen-Induced Eosinophil Recruitment into the Tissue"],"prefix":"10.1159","volume":"125","author":[{"given":"Masaaki","family":"Kasai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kurasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuo","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.44.1.85"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01535-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.195"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.573"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1527"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.1.177"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1671"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000053564"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1993.1013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/332843a0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/341541a0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.255"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1145"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.109"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03496-6"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:54Z","timestamp":1745468934000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000053856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":16,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2001,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000053856","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2001]]}}}