{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:10:00Z","timestamp":1772896200639,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2002]]},"abstract":"<i>Background:<\/i> Since antigen-specific IgE and eosinophils are major inducing factors of allergic inflammation of the airways, both factors are therapeutic targets of asthma. We investigated the effects of ONO-4007, a nontoxic lipid A analogue, on antigen-specific antibody response and the recruitment of eosinophils into airways in murine systems. <i>Methods:<\/i> BALB\/c mice were injected ONO-4007 intraperitoneally during sensitization with ovalbumin (OVA) and aluminium hydroxide to determine its effects on the antigen-specific antibody response. ONO-4007 was also injected intravenously during either systemic sensitization and inhalation with OVA, or sensitization or inhalation alone to determine its effects on antigen-induced airway inflammation. In vitro effects of ONO-4007 on the functional differentiation of naive CD4<sup>+<\/sup> T cells were investigated by culturing naive CD4<sup>+<\/sup> T cells derived from DO11.10 mice and OVA-pulsed dendritic cells (CDCs) with ONO-4007. <i>Results:<\/i> ONO-4007 inhibited antigen-specific IgE and IgG<sub>1<\/sub>, but not IgG<sub>2a<\/sub> responses. ONO-4007 decreased the recruitment of eosinophils and the levels of IL-5 in bronchoalveolar lavage fluid, not only when it was injected during systemic sensitization and inhalation with OVA, but also during inhalation alone. ONO-4007 inhibited the differentiation of IL-4- and IL-13-producing CD4<sup>+<\/sup> T cells in vitro, which was partly mediated by DCs. <i>Conclusions:<\/i> ONO-4007 inhibited antigen-specific IgE and IgG<sub>1<\/sub> responses and antigen-induced eosinophil recruitment into the airways in BALB\/c mice. These effects were mediated, at least partly, by the modulation of DCs, although there may also be other mechanisms.<\/jats:p>","DOI":"10.1159\/000053866","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"217-225","source":"Crossref","is-referenced-by-count":5,"title":["Lipid A Analogue, ONO-4007, Inhibits IgE Response and Antigen-Induced Eosinophilic Recruitment into Airways in BALB\/c Mice"],"prefix":"10.1159","volume":"127","author":[{"given":"Jun","family":"Iio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Katamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Ohmura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yasumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taka-aki","family":"Meguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusei","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsutoshi","family":"Nakahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.12.1.227"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.43"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.5141"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/26239"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.11.2091"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.12.1981"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01427-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/79758"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2085"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.12.1.635"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.297"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/35051100"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.3.587"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:59Z","timestamp":1745468939000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000053866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000053866","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}