{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:08:04Z","timestamp":1761674884928,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate a policy of selective rather than routine use of amniocentesis for advanced maternal age. &lt;i&gt;Method:&lt;\/i&gt; A consecutive series of 359 pregnant women aged 38\u201347 underwent nuchal translucency measurement (NTM) at 10\u201314 weeks, maternal serum screening (MSS) by \u03b1-fetoprotein (AFP) and human chorionic gonadotropin (hCG) at 15\u201317 weeks, and second trimester ultrasound at 21\u201323 weeks. Women with NTM &lt;3 mm, MSS-derived risk &lt;1\/250, and a normal second trimester sonography were considered at low risk and were suggested not to have an amniocentesis. &lt;i&gt;Results:&lt;\/i&gt; Either the NTM or MSS test was positive in 130 women; 105 (81%) of them elected to have an amniocentesis, versus 122 (53%) of 229 in whom both tests were negative (p &lt; 0.001). Nineteen (5%) of 359 patients had NTM \u22673 mm; all 7 cases of Down\u2019s syndrome were in this group; 122 (34%) of 359 patients had a MSS-derived risk \u22671\/250; 6 of the 7 cases of Down\u2019s syndrome were in this group: Ten patients had an abnormal second trimester ultrasound, 1 of which had trisomy 18. Of the 219 patients with MSS-derived risk &lt;1\/250, a NTM &lt;3 mm, and a normal second trimester ultrasound, none had a baby with a chromosomal abnormality (95% confidence interval: 0\u20131.4%). &lt;i&gt;Conclusion:&lt;\/i&gt; Amniocentesis may be offered on a selective rather than routine basis in women over 38, based upon the results of noninvasive screening tests.<\/jats:p>","DOI":"10.1159\/000053943","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"372-377","source":"Crossref","is-referenced-by-count":14,"title":["Is Routine Amniocentesis for Advanced Maternal Age Still Indicated?"],"prefix":"10.1159","volume":"16","author":[{"given":"Marc","family":"Dommergues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Audibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarisse","family":"Benattar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Champagne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Gomel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10050321.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02449-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)12346-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000020900"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05010015.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404213301603"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000020869"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09040244.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10040261.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(96)01817-8"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/53943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:29:52Z","timestamp":1745468992000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000053943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2001,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000053943","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2001]]}}}