{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:42:47Z","timestamp":1758818567042,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>The interaction between renal nerves, endothelins acting via endothelin-A receptors and vasopressin in the regulation of renal excretory function was investigated. In conscious intact and renal denervated diabetes insipidus (DI) Brattleboro rats, as well as their controls, Long-Evans (LE) rats, an infusion of 16.4 nmol\/kg\/min ET&lt;sub&gt;A&lt;\/sub&gt; receptor antagonist BQ-123 was performed in the course of 50 min. Femoral artery blood pressure, heart rate, C&lt;sub&gt;cr&lt;\/sub&gt;, V \u00b7 U&lt;sub&gt;Na&lt;\/sub&gt;, V \u00b7 U&lt;sub&gt;K&lt;\/sub&gt; and V \u00b7 U&lt;sub&gt;Cl&lt;\/sub&gt; did not alter in any of the groups. Urine flow rate diminished by 38.1% (p &lt; 0.02), while urine osmolality increased by 30.3% (p &lt; 0.05) as a result of BQ-123 infusion in the intact LE rats but neither urine flow rate nor urine osmolality changed in the DI rats. In contrast to intact LE rats, BQ-123 infusion in renal denervated LE rats did not alter urine flow rate or urine osmolality. However, urine flow rate in renal denervated DI rats surprisingly decreased by 71.1% (p &lt; 0.01) while urine osmolality increased by 161% (p &lt; 0.001) as a result of BQ-123 infusion. Endogenous endothelins can regulate renal water excretion through ET&lt;sub&gt;A&lt;\/sub&gt; receptor activation. Renal sympathetic nerves participate in the modulation of renal water excretion influencing the ET&lt;sub&gt;A&lt;\/sub&gt; receptor-mediated effects of endothelins in the kidney.<\/jats:p>","DOI":"10.1159\/000054199","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"5-9","source":"Crossref","is-referenced-by-count":2,"title":["Involvement of Renal Nerves and Endothelins in the Regulation of Renal Water Excretion in Diabetes insipidus Rats"],"prefix":"10.1159","volume":"24","author":[{"given":"Radoslav","family":"Girchev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petia","family":"Markova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitar","family":"Mikhov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Avramova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natcho","family":"Nattcheff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90081-D"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90718-J"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:01Z","timestamp":1745468701000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000054199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":2,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000054199","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2001]]}}}