{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:12:51Z","timestamp":1745554371979,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;b&gt;Aims and Methods:&lt;\/b&gt; Our aim was to evaluate the antihypertensive efficacy and tolerability of angiotensin II type 1 (AT&lt;sub&gt;1&lt;\/sub&gt;) receptor antagonists. Valsartan or candesartan cilexetil was administered to 11 dialysis patients with elevated blood pressure. The patients (6 male, 5 female; mean age \u00b1 SD 61\u00b111 years) were on regular bicarbonate hemodialysis three times weekly for more than 3 months using acrylonitrile and sodium methallyl sulfonate copolymer (AN69) dialysis membranes. &lt;b&gt;Results:&lt;\/b&gt; Within 252 days after administration of the AT&lt;sub&gt;1&lt;\/sub&gt; receptor antagonists the systolic blood pressure was significantly reduced from 161\u00b113 to 130\u00b112 mmHg (p&lt;0.001), whereas the diastolic blood pressure did not change significantly (76\u00b18 vs. 71\u00b18 mmHg; p&gt;0.05). In addition, heart rate (75\u00b17 vs. 80\u00b18\/min), body weight, and laboratory variables (hemoglobin, creatinine, blood urea nitrogen, serum potassium, serum sodium, serum calcium, and total protein) showed no significant changes. During 1,188 hemodialysis sessions using AN69 membranes, no hypersensitivity reactions occurred after administration of AT&lt;sub&gt;1&lt;\/sub&gt; receptor antagonists. &lt;b&gt;Conclusion:&lt;\/b&gt; The results indicate that once\u2013daily administration of AT&lt;sub&gt;1&lt;\/sub&gt; receptor antagonists efficiently reduces the systolic blood pressure in hemodialysis patients.<\/jats:p>","DOI":"10.1159\/000054209","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"71-74","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and Tolerability of Angiotensin II Type 1 Receptor Antagonists in Dialysis Patients Using AN69 Dialysis Membranes"],"prefix":"10.1159","volume":"24","author":[{"given":"Martin","family":"Tepel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"van der Giet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Zidek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810083391507"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92693-N"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.156.17.1957"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199905000-00016"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000045257"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:03Z","timestamp":1745468703000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000054209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000054209","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2001]]}}}