{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:32:36Z","timestamp":1759048356775,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To examine the regulation of interferon (IFN)-\u03b3 release by cells derived from submaxillary lymph nodes of rats subjected to an acute or chronic superior cervical ganglionectomy (SCGx). &lt;i&gt;Methods:&lt;\/i&gt; A unilateral SCGx and a contralateral sham operation were performed. Twenty hours or 7 days later cells from submaxillary lymph nodes were incubated for 24 h without any additional treatment (experiment 1), after adding lipopolysaccharide or concanavalin A (experiment 2) or after adding norepinephrine (NE, 10&lt;sup&gt;\u20138&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt;; experiment 3). IFN-\u03b3 concentration in the culture media was measured by ELISA. &lt;i&gt;Results:&lt;\/i&gt; Compared to controls, cells obtained from lymph nodes at a time of degeneration of sympathetic nerve terminals released more IFN-\u03b3, whereas those derived from chronically SCGx lymph nodes released less IFN-\u03b3. Stimulation of IFN-\u03b3 release by mitogens was detectable in the innervated or acutely denervated lymph nodes, but not in chronically denervated lymph nodes. When the effect of 10&lt;sup&gt;\u20138&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt; NE on IFN-\u03b3 release was tested, the neurotransmitter augmented cytokine release in cells prepared from chronically denervated lymph nodes only. &lt;i&gt;Conclusion:&lt;\/i&gt; The microenvironment provided by local sympathetic nerves is essential to enable an appropriate IFN-\u03b3 release by submaxillary lymph node cells to occur.<\/jats:p>","DOI":"10.1159\/000054280","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"197-202","source":"Crossref","is-referenced-by-count":9,"title":["Interferon-Gamma Release in Sympathetically Denervated Rat Submaxillary Lymph Nodes"],"prefix":"10.1159","volume":"8","author":[{"given":"Patricia O.","family":"Castrill\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Cardinali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Arce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo A.","family":"Cutrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana I.","family":"Esquifino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/er.17.1.64"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2274"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90183-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<3980::AID-IMMU3980>3.3.CO;2-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.693"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90516-S"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:26Z","timestamp":1745468726000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000054280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000054280","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"type":"print","value":"1021-7401"},{"type":"electronic","value":"1423-0216"}],"subject":[],"published":{"date-parts":[[2000]]}}}