{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:35:23Z","timestamp":1790854523104,"version":"4.1.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Apolipoprotein E (ApoE) phenotyping was determined in 42 subjects with Alzheimer\u2019s disease (AD), 49 with depression, including 26 with early-onset depression (EOD) and 23 with late-onset depression (LOD), and 49 controls. In the EOD group, the frequency of the ApoE &amp;#917;4 allele was not different from the control frequency (p = 0.532) but was significantly lower than in AD (p &lt; 0.001). In the LOD group, the ApoE &amp;#917;4 frequency was significantly higher than in the controls (p = 0.034) but was not different from that in the AD group (p = 0.229). Individuals with ApoE &amp;#917;4 were at greater risk of getting AD (odds ratio, OR = 5.5, 95% confidence interval, CI, 2.0\u201314.0) or LOD (OR = 6.1, 95% CI, 1.9\u201319.0) than of EOD (OR = 0.7, 95% CI, 0.2\u20132.5). These results suggest an association between the ApoE &amp;#917;4 allele frequency and LOD. Patients with LOD could be at risk of developing AD by an &amp;#917;4-dependent pathway.<\/jats:p>","DOI":"10.1159\/000054801","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"268-272","source":"Crossref","is-referenced-by-count":41,"title":["Association of the Apolipoprotein E \u03b54 Allele with Late-Onset Depression"],"prefix":"10.1159","volume":"20","author":[{"given":"Anne-Sophie","family":"Rigaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latchezar","family":"Traykov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Coste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Latour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Couderc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Boller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Forette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,10,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000017129"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90033-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90245-U"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004576"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004199"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajgp.8.3.196"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00247-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90607-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.1999.640415.x"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:02Z","timestamp":1745469062000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000054801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000054801","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}