{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:45:41Z","timestamp":1758969941660,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>In this study, we examined the effect of the subcutaneous administration (twice daily for 4 consecutive days) of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg\/kg) or saline (1 ml\/kg) on the response of rats to the behavioral effects of the 5-HT1A agonist (\u00b1)-8-hydroxy-(di-n-propylamino)tetralin (8-OH-DPAT) 30 days after the last saline or MDMA treatment. The reciprocal forepaw treading elicited by the 0.25-mg\/kg dose of 8-OH-DPAT was significantly lower in animals pretreated with MDMA compared to vehicle-treated animals. However, there were no significant differences between the MDMA- and vehicle-treated animals in flat body posture, locomotor activity and rectal temperature measured after the systemic administration of 8-OH-DPAT. Overall, our results suggest that the depletion of 5-HT levels by the repeated administration of MDMA does not produce a supersensitivity of central 5-HT1A receptors in the rat as determined via our approach.<\/jats:p>","DOI":"10.1159\/000054864","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"42-48","source":"Crossref","is-referenced-by-count":13,"title":["Effect of the Repeated Administration of (\u00b1)-3,4-Methylenedioxymethamphetamine on the Behavioral Response of Rats to the 5-HT1A Receptor Agonist (\u00b1)-8-Hydroxy-(di-n-Propylamino)Tetralin"],"prefix":"10.1159","volume":"43","author":[{"given":"Martin I.","family":"Granoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Ashby Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90566-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90974-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90714-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90032-L"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90032-L"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)94172-T"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90509-1"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/54864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:35Z","timestamp":1745469095000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000054864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000054864","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[2001]]}}}