{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:07:43Z","timestamp":1780103263886,"version":"3.54.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Objective: &lt;\/i&gt;To investigate whether the three principal components of the insulin-like growth factor (IGF) system, IGF-1, IGF-2 and IGF binding protein-3 (IGFBP-3), are associated with survival from childhood leukemia. &lt;i&gt;Patients and Methods:&lt;\/i&gt; 116 children, 0\u201314 years old, with newly diagnosed and bone-marrow-biopsy-confirmed acute childhood leukemia between 1993 and 1996 were followed up until death or March 31, 1998. IGF-1, IGF-2 and IGFBP-3 were measured at diagnosis and clinical data, including presence of hepatosplenomegaly and number of white blood cells, were available. &lt;i&gt;Results:&lt;\/i&gt; After controlling for gender, age, indicators of clinical severity and the other measured components of the IGF system there was a statistically significant (p &lt; 0.05) inverse association of IGFBP-3 with survival. An increment of one standard deviation in IGFBP-3 was associated with a 65% reduction of the death hazard among the children with leukemia. Neither IGF-1 nor IGF-2 was associated with survival in this data set. &lt;i&gt;Conclusion:&lt;\/i&gt; The presented empirical evidence in conjunction with the fact that IGFBP-3 modulates IGF-1 and IGF-2 bioavailability and is likely to have proapoptotic effects makes this compound a plausible independent predictor of survival from childhood leukemia.<\/jats:p>","DOI":"10.1159\/000055326","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"252-257","source":"Crossref","is-referenced-by-count":15,"title":["Insulin-Like Growth Factor Binding Protein-3 Predicts Survival from Acute Childhood Leukemia"],"prefix":"10.1159","volume":"60","author":[{"given":"Eleni","family":"Petridou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkistis","family":"Skalkidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Dessypris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Moustaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Mantzoros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evagelos","family":"Spanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Trichopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.563"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<15::AID-IJC4>3.3.CO;2-P"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10384-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000011858"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s004320050259"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050379"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990209)80:4<494::AID-IJC2>3.0.CO;2-K"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.12181"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25602"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09412-3"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/55326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/55326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:56Z","timestamp":1745469416000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000055326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000055326","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}