{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:24:20Z","timestamp":1758122660524,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1998,12,2]],"date-time":"1998-12-02T00:00:00Z","timestamp":912556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,12,2]],"date-time":"1998-12-02T00:00:00Z","timestamp":912556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; We analyzed the preventive effect of immunoglobulins for intravenous use (IVIgs) in endotoxin-induced uveitis (EIU), a disease related to tumor necrosis factor \u03b1 (TNF-\u03b1) production. &lt;i&gt;Materials and Methods:&lt;\/i&gt; EIU was the experimental model in Lewis rats, injecting a systemic dose of 150\u00a0\u00b5g of lipopolysaccharide (LPS) into the rat\u2019s footpad. Half of them were treated with 5 serial intravenous doses of 100\u00a0mg of IVIg during the 5 days prior to LPS injection. Eyes were repeatedly examined with a slitlamp, rats were killed and their eyes enucleated for histopathologic study at the 2nd, 16th and 24th hours. TNF-\u03b1 serum levels were measured in aqueous humor at several time intervals by a bioassay using L-929 mouse fibroblasts. Aqueous humor proteins were detected by the Bradford method. &lt;i&gt;Results:&lt;\/i&gt; IVIg treatment prevented EIU development, treated animals showing a lower grade of ocular inflammation beyond the 2nd hour (Fisher test, p &gt; 0.05). Inflammatory cell infiltration was significantly reduced in the iris, ciliary body and anterior chamber at a 24-hour interval (Wilcoxon test, p &lt; 0.05). This protection was associated with lower levels of TNF-\u03b1 in serum at all time intervals and in aqueous humor at 16\u00a0h (Student\u2019s t test, p &lt; 0.05), while differences were not significant between the samples of aqueous humor collected at 2\u00a0h. Protein exudate was not reduced in the treated group. &lt;i&gt;Conclusions:&lt;\/i&gt; Repeated IVIg injections could be useful in the preventive treatment of EIU probably mediated by a decrease in TNF-\u03b1 release.<\/jats:p>","DOI":"10.1159\/000055514","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"59-67","source":"Crossref","is-referenced-by-count":7,"title":["Human Immunoglobulin Preparations for Intravenous Use Prevent Endotoxin-Induced Uveitis in Rats"],"prefix":"10.1159","volume":"31","author":[{"given":"Esther","family":"Obrador","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Peinado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"de Kozak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoseM.","family":"Ruiz-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JorgeL.","family":"Alio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1976.9999"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(84)90147-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90141-4"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/55514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/55514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:38:47Z","timestamp":1745469527000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000055514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12,2]]},"references-count":3,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000055514","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[1998,12,2]]}}}