{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:15:44Z","timestamp":1774991744880,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1159\/000055843","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"432-438","source":"Crossref","is-referenced-by-count":39,"title":["Gene Mutations in Children with Chronic Pancreatitis"],"prefix":"10.1016","volume":"1","author":[{"given":"Heiko","family":"Witt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1159\/000055843_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0016-5085(52)80120-9","article-title":"Pedigree of a family with hereditary chronic relapsing pancreatitis","volume":"21","author":"Comfort","year":"1952","journal-title":"Gastroenterology"},{"key":"10.1159\/000055843_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/00365528209182047","article-title":"Incidence of alcoholic chronic pancreatitis in Copenhagen","volume":"17","author":"Andersen","year":"1982","journal-title":"Scand J Gastroenterol"},{"key":"10.1159\/000055843_bib3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00006676-198707000-00002","article-title":"Differences in the natural history of idiopathic (nonalcoholic) and alcoholic chronic pancreatitis. A comparative long-term study of 287 patients","volume":"2","author":"Ammann","year":"1987","journal-title":"Pancreas"},{"key":"10.1159\/000055843_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0031-3955(05)70400-4","article-title":"Pancreatic diseases in children","volume":"43","author":"Lerner","year":"1996","journal-title":"Pediatr Clin North Am"},{"key":"10.1159\/000055843_bib5","first-page":"69","article-title":"\u00dcber Selbstverdauung des menschlichen Pankreas","volume":"17","author":"Chiari","year":"1896","journal-title":"Z Heilkd"},{"key":"10.1159\/000055843_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1056\/NEJM198701153160306","article-title":"The cell biology of experimental pancreatitis","volume":"316","author":"Steer","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1159\/000055843_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng1096-141","article-title":"Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene","volume":"14","author":"Whitcomb","year":"1996","journal-title":"Nat Genet"},{"key":"10.1159\/000055843_bib8","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1053\/gast.1997.v113.pm9322498","article-title":"Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis","volume":"113","author":"Gorry","year":"1997","journal-title":"Gas-troenterology"},{"key":"10.1159\/000055843_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1098-1004(1998)12:1<39::AID-HUMU6>3.0.CO;2-P","article-title":"Mutations of the cationic trypsinogen in hereditary pancreatitis","volume":"12","author":"Teich","year":"1998","journal-title":"Hum Mutat"},{"key":"10.1159\/000055843_bib10","first-page":"228","article-title":"Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis","volume":"36","author":"Ferec","year":"1999","journal-title":"J Med Genet"},{"key":"10.1159\/000055843_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0016-5085(99)70543-3","article-title":"A signal peptide cleavage site mutation in the cationic trypsino-gen gene is strongly associated with chronic pancreatitis","volume":"117","author":"Witt","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1159\/000055843_bib12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1053\/gast.2000.9312","article-title":"Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation","volume":"119","author":"Teich","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1159\/000055843_bib13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/bbrc.2000.3797","article-title":"Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen","volume":"278","author":"Sahin-Toth","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1159\/000055843_bib14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/ja01189a060","article-title":"Isolation of a crystalline trypsin inhibitor-anticoagulant protein from the pancreas","volume":"70","author":"Kazal","year":"1948","journal-title":"J Am Chem Soc"},{"key":"10.1159\/000055843_bib15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0021-9258(18)66082-X","article-title":"Temporary inhibition of trypsin","volume":"204","author":"Laskowski","year":"1953","journal-title":"J Biol Chem"},{"key":"10.1159\/000055843_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/76088","article-title":"Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis","volume":"25","author":"Witt","year":"2000","journal-title":"Nat Genet"},{"key":"10.1159\/000055843_bib17","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1053\/gast.2000.18017","article-title":"SPINK1\/PSTI polymorphisms act as disease modifiers in familial and idio-pathic chronic pancreatitis","volume":"119","author":"Pf\u00fctzer","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1159\/000055843_bib18","series-title":"Textbook of Gastroenterology, ed 2_ {pl_Philadelphia","first-page":"1874","article-title":"Chronic pancreatitis }","author":"Owyang","year":"1991"},{"key":"10.1159\/000055843_bib19","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1053\/gast.2001.23086","article-title":"SPINK1 mutations in chronic pancreatitis","volume":"120","author":"Witt","year":"2001","journal-title":"Gastroenterol-ogy"},{"key":"10.1159\/000055843_bib20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1542\/peds.55.1.86","article-title":"Recurrent acute pancreatitis in patients with cystic fibrosis with normal pancreatic enzymes","volume":"55","author":"Shwachman","year":"1975","journal-title":"Pediatrics"},{"key":"10.1159\/000055843_bib21","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJM199809033391002","article-title":"Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis","volume":"339","author":"Cohn","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1159\/000055843_bib22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJM199809033391001","article-title":"Mutations of the cystic fibrosis gene in patients with chronic pancreatitis","volume":"339","author":"Sharer","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1159\/000055843_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0954-6111(98)90278-5","article-title":"ai-Antitrypsin deficiency in Europe: Geographical distribution of Pi types S and Z","volume":"92","author":"Hutchison","year":"1998","journal-title":"Respir Med"},{"key":"10.1159\/000055843_bib24","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0140-6736(75)90728-X","article-title":"Chronic pancreatitis and alpha-1-antitrypsin","volume":"ii","author":"Novis","year":"1975","journal-title":"Lancet"},{"key":"10.1159\/000055843_bib25","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0140-6736(76)90883-7","article-title":"Alpha1-antitrypsin and chronic pancreatitis","volume":"ii","author":"Mihas","year":"1976","journal-title":"Lancet"},{"key":"10.1159\/000055843_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000198693","article-title":"Alpha1-antitrypsin in pancreatitis","volume":"23","author":"Braxel","year":"1982","journal-title":"Digestion"},{"key":"10.1159\/000055843_bib27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000198194","article-title":"\u00b7^Antitrypsin in pancreatic diseases","volume":"18","author":"Lankisch","year":"1978","journal-title":"Digestion"},{"key":"10.1159\/000055843_bib28","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/gut.32.8.945","article-title":"a1 Antitrypsin phenotypes and alcoholic pancreatitis","volume":"32:","author":"Haber","year":"1991","journal-title":"Gut"},{"key":"10.1159\/000055843_bib29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.bi.49.070180.003113","article-title":"Protein inhibitors of proteinases","volume":"49","author":"Laskowski M","year":"1980","journal-title":"Annu Rev Biochem"},{"key":"10.1159\/000055843_bib30","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF01318124","article-title":"Activation of pancreatic zy-mogens. Normal activation, premature intra-pancreatic activation, protective mechanisms against inappropriate activation","volume":"31","author":"Rinderknecht","year":"1986","journal-title":"Dig Dis Sci"},{"key":"10.1159\/000055843_bib31","first-page":"657","article-title":"Mechanisms to explain pancreatic dysfunction in cystic fibrosis","volume":"84","author":"Freedman","year":"2000","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1159\/000055843_bib32","first-page":"549","article-title":"Early trypsinogen activation in acute pancreatitis","volume":"84","author":"Lerch","year":"2000","journal-title":"Gastroenterol Clin North Am"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390301800740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390301800740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T15:36:25Z","timestamp":1682350585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390301800740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S1424390301800740"],"URL":"https:\/\/doi.org\/10.1159\/000055843","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}