{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:27:18Z","timestamp":1761290838308},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1159\/000055855","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"525-530","source":"Crossref","is-referenced-by-count":10,"title":["Timing and Extent of Surgical Intervention in Patients from Hereditary Pancreatic Cancer Kindreds"],"prefix":"10.1016","volume":"1","author":[{"given":"Panagiotis B.","family":"Kekis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Friess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Kleeff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus W.","family":"B\u00fcchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1159\/000055855_bib1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/1097-0142(19951101)76:9<1671::AID-CNCR2820760926>3.0.CO;2-R","article-title":"The National {jt_Cancer","volume":"76","author":"Niederhuber","year":"1995","journal-title":"Cancer"},{"key":"10.1159\/000055855_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF02924156","article-title":"Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada","volume":"10","author":"Ghadirian","year":"1991","journal-title":"Int J Pancreatol"},{"key":"10.1159\/000055855_bib3","first-page":"251","article-title":"Familial pancreatic cancer: A review","volume":"23","author":"Lynch","year":"1996","journal-title":"Semin Oncol"},{"key":"10.1159\/000055855_bib4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0025-7125(05)70249-2","article-title":"Hereditary pancreatic adenocarcinoma. A clinical perspective","volume":"84","author":"Brand","year":"2000","journal-title":"Med Clin North Am"},{"key":"10.1159\/000055855_bib5","first-page":"409","article-title":"Inherited predisposition to pancreatic adenocarcinoma: Role of family history and germ-line p16, BRCA1, and BRCA2 mutations","volume":"60","author":"Lal","year":"2000","journal-title":"Cancer Res"},{"key":"10.1159\/000055855_bib6","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0002-9440(10)65440-5","article-title":"Germline and somatic mutations of the STK11\/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers","volume":"154","author":"Su","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1159\/000055855_bib7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/bega.1999.0023","article-title":"Hereditary pancreatitis: New insights, new directions","volume":"13","author":"Whitcomb","year":"1999","journal-title":"Baillieres Best Pract Res Clin Gastroenterol"},{"key":"10.1159\/000055855_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-131-4-199908170-00003","article-title":"Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer","volume":"131","author":"Brentnall","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1159\/000055855_bib9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0025-7125(05)70253-4","article-title":"Cancer surveillance of patients from familial pancreatic cancer kindreds","volume":"84","author":"Brentnall","year":"2000","journal-title":"Med Clin North Am"},{"key":"10.1159\/000055855_bib10","first-page":"1099","article-title":"Ductal epithelial lesions and pancreatic adenocarcinoma (in Spanish)","volume":"118","author":"Bentjerodt","year":"1990","journal-title":"Rev Med Chil"},{"key":"10.1159\/000055855_bib11","first-page":"3","article-title":"Dysplasia and carcinoma in situ of the pancreatic duct epithelium (in German)","volume":"134","author":"Schulz","year":"1988","journal-title":"Zentralbl Allg Pathol"},{"key":"10.1159\/000055855_bib12","first-page":"2690","article-title":"Morphological lesions associated with human primary invasive nonendocrine pancreas cancer","volume":"36","author":"Cubilla","year":"1976","journal-title":"Cancer Res"},{"key":"10.1159\/000055855_bib13","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/1097-0142(197904)43:4<1418::AID-CNCR2820430431>3.0.CO;2-O","article-title":"Relation of pancreatic duct hyperplasia to carcinoma","volume":"43","author":"Kozuka","year":"1979","journal-title":"Cancer"},{"key":"10.1159\/000055855_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jcb.240501108","article-title":"The adenoma-adenocarcinoma sequence in the large bowel: Variations on a theme","volume":"16G","author":"Hamilton","year":"1992","journal-title":"J Cell Biochem Suppl"},{"key":"10.1159\/000055855_bib15","first-page":"229","article-title":"Pathology of the adenoma-carcinoma sequence: From aberrant crypt focus to invasive carcinoma","volume":"11","author":"Cummings","year":"2000","journal-title":"Semin Gastrointest Dis"},{"key":"10.1159\/000055855_bib16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/s002689900593","article-title":"Diagnosis and staging of pancreatic cancer by positron emission tomography","volume":"23","author":"Berberat","year":"1999","journal-title":"World J Surg"},{"key":"10.1159\/000055855_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0016-5107(91)70729-3","article-title":"Endo-scopic ultrasound in pancreatic tumor diagnosis","volume":"37","author":"Rosch","year":"1991","journal-title":"Gastrointest Endosc"},{"key":"10.1159\/000055855_bib18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1148\/radiology.195.2.7724751","article-title":"Evaluation of pancreatic tumors with positron emission tomography and F-18 fluorodeoxyglucose: Comparison with CT and US","volume":"195","author":"Inokuma","year":"1995","journal-title":"Radiology"},{"key":"10.1159\/000055855_bib19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1148\/radiology.190.3.8115622","article-title":"Pancreatic tumors: Evaluation with endoscopic US, CT, and MR imaging","volume":"190","author":"Muller","year":"1994","journal-title":"Radiology"},{"key":"10.1159\/000055855_bib20","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1572-0241.2000.01976.x","article-title":"Endoscopic ultrasound characteristics of mucinous cystic neoplasms of the pancreas","volume":"95","author":"Gress","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1159\/000055855_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.7326\/0003-4819-134-6-200103200-00010","article-title":"Endoscopic ultrasonography-guided fine-needle aspiration biopsy of suspected pancreatic cancer","volume":"134","author":"Gress","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1159\/000055855_bib22","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0016-5107(99)70159-8","article-title":"Role of EUS in the preoperative staging of pancreatic cancer: A large single-center experience","volume":"50","author":"Gress","year":"1999","journal-title":"Gastrointest En-dosc"},{"issue":"suppl 4","key":"10.1159\/000055855_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/annonc\/10.suppl_4.S140","article-title":"Pancreatic cancer: Clinical presentation, pitfalls and early clues","volume":"10","author":"Di Magno","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1159\/000055855_bib24","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1111\/j.1572-0241.2000.02312.x","article-title":"Modern imaging methods versus clinical assessment in the evaluation of hospital in-patients with suspected pancreatic disease","volume":"95","author":"Rosch","year":"2000","journal-title":"Am J Gastroente-rol"},{"key":"10.1159\/000055855_bib25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1572-0241.2001.03594.x","article-title":"Complications of diagnostic and therapeutic ERCP: A prospective multicenter study","volume":"96","author":"Masci","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1159\/000055855_bib26","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1148\/radiology.217.3.r00dc24757","article-title":"Intraductal papillary mucinous tumors of the pancreas: Helical CT with histopathologic correlation","volume":"217","author":"Taouli","year":"2000","journal-title":"Radiology"},{"key":"10.1159\/000055855_bib27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s002619900365","article-title":"Endoscopic ultrasound and intraductal ultrasound in the diagnosis of small pancreatic tumors","volume":"23","author":"Ariyama","year":"1998","journal-title":"Abdom Imaging"},{"key":"10.1159\/000055855_bib28","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/gut.36.5.771","article-title":"Diagnosis of pancreatic cancer by 2[18F]-fluoro-2-deoxy-D-glucose positron emission tomography","volume":"36","author":"Friess","year":"1995","journal-title":"Gut"},{"key":"10.1159\/000055855_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1148\/radiology.195.2.7724750","article-title":"2-(Fluorine-18)-fluoro-2-deoxy-D-glucose PET in detection of pancreatic cancer: Value of quantitative image interpretation","volume":"195","author":"Stollfuss","year":"1995","journal-title":"Radiology"},{"issue":"suppl 4","key":"10.1159\/000055855_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/annonc\/10.suppl_4.S153","article-title":"Biliopancreatic malignancy: Screening the at risk patient with molecular markers","volume":"10","author":"aldas","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1159\/000055855_bib31","first-page":"515","article-title":"K-ras mutation in focal prolifera-tive lesions of human pancreas","volume":"7","author":"Terhune","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1159\/000055855_bib32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00000658-199710000-00010","article-title":"Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas","volume":"226","author":"Z'Graggen","year":"1997","journal-title":"Ann Surg"},{"key":"10.1159\/000055855_bib33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1385\/IJGC:27:2:093","article-title":"K-Ras mutations and benign pancreatic disease","volume":"27","author":"Lohr","year":"2000","journal-title":"Int J Pancreatol"},{"key":"10.1159\/000055855_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1055-3207(18)30286-2","article-title":"CA 19-9 in pancreatic cancer","volume":"7","author":"Ritts","year":"1998","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1159\/000055855_bib35","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0016-5107(99)70161-6","article-title":"EUS and K-ras analysis of pure pancreatic juice collected via a duode-noscope after secretin stimulation for diagnosis of pancreatic mass lesion: A prospective study","volume":"50","author":"Okai","year":"1999","journal-title":"Gastrointest Endosc"},{"key":"10.1159\/000055855_bib36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000478-199802000-00003","article-title":"Progression of pancreatic intra-ductal neoplasias to infiltrating adenocarcino-ma of the pancreas","volume":"22","author":"Brat","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1159\/000055855_bib37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0025-7125(05)70256-X","article-title":"Surgical management of hereditary pancreatic cancer","volume":"84","author":"Davis","year":"2000","journal-title":"Med Clin North Am"},{"issue":"suppl 1","key":"10.1159\/000055855_bib38","first-page":"23","article-title":"Surgery of hereditary colorectal carcinoma (in German)","volume":"125","author":"Pistorius","year":"2000","journal-title":"Zentralbl Chir"},{"key":"10.1159\/000055855_bib39","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1053\/ejso.2000.0974","article-title":"Hereditary non-polyposis colorec-tal cancer: An updated review","volume":"26","author":"Anwar","year":"2000","journal-title":"Eur J Surg Oncol"},{"key":"10.1159\/000055855_bib40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199901143400201","article-title":"Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer","volume":"340","author":"Hartmann","year":"1999","journal-title":"N Engl J Med"},{"issue":"suppl 4","key":"10.1159\/000055855_bib41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/annonc\/10.suppl_4.S69","article-title":"Familial pancreatic cancer","volume":"10","author":"Hruban","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1159\/000055855_bib42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/1096-9098(200008)74:4<243::AID-JSO1>3.0.CO;2-C","article-title":"Can we screen high-risk individuals to detect early pancreatic carcinoma?","volume":"74","author":"Goggins","year":"2000","journal-title":"J Surg Oncol"},{"key":"10.1159\/000055855_bib43","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1024\/1023-9332.6.5.264","article-title":"Surgery of pancreatic carcinoma (in German)","volume":"6","author":"Wagner","year":"2000","journal-title":"Swiss Surg"},{"key":"10.1159\/000055855_bib44","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1046\/j.1365-2168.2000.01465.x","article-title":"Pancreatic fistula after pancreatic head resection","volume":"87","author":"B\u00fcchler","year":"2000","journal-title":"Br J Surg"},{"key":"10.1159\/000055855_bib45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000018743","article-title":"Prevention and treatment of complications in pancreatic cancer surgery","volume":"16","author":"Berberat","year":"1999","journal-title":"Dig Surg"},{"key":"10.1159\/000055855_bib46","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1072-7515(98)00100-8","article-title":"The role of diagnostic lapa-roscopy in pancreatic and periampullary malignancies","volume":"186","author":"Friess","year":"1998","journal-title":"J Am Coll Surg"},{"key":"10.1159\/000055855_bib47","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/ejso.1998.0613","article-title":"The impact of different types of surgery in pancreatic cancer","volume":"25","author":"Friess","year":"1999","journal-title":"Eur J Surg Oncol"},{"key":"10.1159\/000055855_bib48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000051476","article-title":"The role of octreotide in the prevention of complications following pancreatic resection","volume":"60","author":"Berberat","year":"1999","journal-title":"Digestion"},{"key":"10.1159\/000055855_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1067\/mge.2001.111396","article-title":"Ectopic pancreas located in the major duodenal papilla: Case report and review","volume":"53","author":"Chen","year":"2001","journal-title":"Gas-trointest Endosc"},{"key":"10.1159\/000055855_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00000658-198607000-00009","article-title":"Lymphatic and local spread of T1 and T2 pancreatic cancer. A study of autopsy material","volume":"204","author":"Nagai","year":"1986","journal-title":"Ann Surg"},{"key":"10.1159\/000055855_bib51","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1091-255X(00)80084-0","article-title":"Randomized prospective trial of pylorus-preserving vs. classic duodenopancrea-tectomy (Whipple procedure): Initial clinical results","volume":"4","author":"Seiler","year":"2000","journal-title":"J Gastrointest Surg"},{"issue":"suppl 4","key":"10.1159\/000055855_bib52","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/annonc\/10.suppl_4.S247","article-title":"Standard surgical treatment in pancreatic cancer","volume":"10","author":"Wagner","year":"1999","journal-title":"Ann Oncol"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390301800867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390301800867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T15:36:23Z","timestamp":1682350583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390301800867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S1424390301800867"],"URL":"https:\/\/doi.org\/10.1159\/000055855","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}